inmunoadmin Curr Opin Immunol. 2024 Sep 21;91:102487. doi: 10.1016/j.coi.2024.102487. Online ahead of print. ABSTRACT A simple definition of life is a system that can self-replicate (proliferation) and self-sustain (metabolism). At the cellular level, metabolism has evolved to drive proliferation, which requires energy and building blocks to duplicate cellular biomass before division. T lymphocytes (or T cells) … Read more
Curr Opin Immunol. 2024 Sep 16;91:102460. doi: 10.1016/j.coi.2024.102460. Online ahead of print. ABSTRACT Since the discovery of Toll and Toll-like receptors (TLRs) in the 90s, an extensive body of research has been performed to determine how Pattern Recognition Receptors (PRRs) recognise ‘ligands’ and signal. The families of PRRs now include membrane and cytosolic proteins, which … Read more
Curr Opin Immunol. 2024 Sep 13;91:102463. doi: 10.1016/j.coi.2024.102463. Online ahead of print. ABSTRACT In tumors, immune cells organize into networks of different sizes and composition, including complex tertiary lymphoid structures and recently identified networks centered around the chemokines CXCL9/10/11 and CCL19. New commercially available highly multiplexed microscopy using cyclical RNA in situ hybridization and antibody-based … Read more
Curr Opin Immunol. 2024 Sep 13;91:102471. doi: 10.1016/j.coi.2024.102471. Online ahead of print. ABSTRACT The microbiome regulates mammalian immune responses from early life to adulthood. Antigen presentation, orchestrating these responses, integrates commensal and pathogenic signals. However, the temporal and spatial specificity of microbiome impacts on antigen presentation and downstream tolerance versus inflammation remain incompletely understood. Herein, … Read more
Curr Opin Immunol. 2024 Sep 13;91:102461. doi: 10.1016/j.coi.2024.102461. Online ahead of print. ABSTRACT T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has … Read more
Curr Opin Immunol. 2024 Sep 11;91:102462. doi: 10.1016/j.coi.2024.102462. Online ahead of print. ABSTRACT Signal integration is central to a causal understanding of appropriately scaled inflammatory responses. Here, we discuss recent progress in our understanding of the stimulus-response linkages downstream of pro-inflammatory inputs, with special attention to (1) the impact of cell state on the specificity … Read more
J Clin Immunol. 2024 Sep 27;45(1):18. doi: 10.1007/s10875-024-01809-3. ABSTRACT INTRODUCTION: This study investigates the frequency of hospital attendances, emergency care attendances and geographical influences on service interaction in cohorts of patients with primary and secondary antibody deficiency, to inform future service planning and delivery. METHODS: The COVID-19 in Antibody Deficiency (COV-AD) study was a United … Read more
J Clin Immunol. 2024 Sep 26;45(1):17. doi: 10.1007/s10875-024-01798-3. ABSTRACT BACKGROUND: Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that causes endemic mycoses, which could lead to multiple organ damage. Talaromycosis is frequently disregarded as an early cautionary sign of immune system disorders in non-HIV-infected children. OBJECTIVE: We conduct a comprehensive review of the genotypes and … Read more
J Clin Immunol. 2024 Sep 25;45(1):16. doi: 10.1007/s10875-024-01807-5. ABSTRACT Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF), is a rare disease with autosomal recessive inheritance. ICF syndrome. It has been reported that ICF syndrome is caused by mutations in the DNMT3B (ICF1), ZBTB24 (ICF2), CDCA7 (ICF3), and HELLS (ICF4) genes. As a result of literature … Read more
J Clin Immunol. 2024 Sep 23;45(1):14. doi: 10.1007/s10875-024-01804-8. NO ABSTRACT PMID:39312089 | PMC:PMC11420255 | DOI:10.1007/s10875-024-01804-8
