Synergy between TLR3-ligand and IFN-{alpha} in the transient sensitization of “Cold” tumors to PD-1 blockade and the induction of systemic immunity
Background
Programmed cell death protein-1 (PD-1)-blocking immune checkpoint inhibitors (ICIs) are effective against highly immunogenic “hot” tumors containing high numbers of cytotoxic T-lymphocytes (CTLs), but not against poorly immunogenic “cold” t…