Liu, S., Pan, Y., Liu, W., Bu, X., Shao, R., Wang, Q., Wu, J., Wu, C., Hu, W., Xu, J., Wu, C., Jiang, J.

Lactylation-driven MVP upregulation boosts immunotherapy resistance by inhibiting PD-L1 degradation in hepatocellular carcinoma

22 de September de 2025 by Liu, S., Pan, Y., Liu, W., Bu, X., Shao, R., Wang, Q., Wu, J., Wu, C., Hu, W., Xu, J., Wu, C., Jiang, J.

Background
Hepatocellular carcinoma (HCC) is a prevalent malignancy and the third leading cause of cancer-related mortality worldwide. Immune checkpoint inhibitors (ICIs) have emerged as first-line therapies for advanced HCC, substantially improving c…