Tang, Z., Shi, J., Xu, S., Liu, S., Yin, W., Xiang, Y., Li, J., He, Z., Yao, X., Li, Z., Xiao, R., Deng, H.

Single-cell multiomics reveals macrophage-derived IL-23 and CXCL9/10 drive pathogenic IFNG+IL17+ T cells in immunotherapy-related colitis

30 de November de 2025 by Tang, Z., Shi, J., Xu, S., Liu, S., Yin, W., Xiang, Y., Li, J., He, Z., Yao, X., Li, Z., Xiao, R., Deng, H.

Background
Immune checkpoint blockade (ICB) therapy, while transformative in cancer treatment, is frequently complicated by immune-related colitis (irColitis), driven by poorly understood mechanisms.

Methods
An integrated analysis of single-cell RNA …

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