Zhou, Y., Zhang, W., Wang, B., Wang, P., Li, D., Cao, T., Zhang, D., Han, H., Bai, M., Wang, X., Zhao, X., Lu, Y.

Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer

3 de March de 20241 de March de 2024 by Zhou, Y., Zhang, W., Wang, B., Wang, P., Li, D., Cao, T., Zhang, D., Han, H., Bai, M., Wang, X., Zhao, X., Lu, Y.

Background
The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and low immune infiltration in most microsatellite-stable (MSS) tumors. This study aimed to develop a mitochondria-…