Zhu, D., Li, Z., Feng, H., Zheng, J., Xiao, X., Huang, Z., Zheng, L., Guo, J., Ling, F., Li, Y., Xing, F.

EZH2 inhibition and 5-azacytidine enhance antitumor immunity in PTEN-deficient glioblastoma by activation viral mimicry response

13 de June de 2025 by Zhu, D., Li, Z., Feng, H., Zheng, J., Xiao, X., Huang, Z., Zheng, L., Guo, J., Ling, F., Li, Y., Xing, F.

Background
PTEN-deficient glioblastoma (GBM) is characterized by an immunosuppressive tumor microenvironment (TME), therapeutic resistance, and poor prognosis. Emerging evidence suggests that dysregulation of the endogenous retrovirus (ERV)-MAVS-IFN p…