Lab-grown human immune system uncovers weakened response in cancer patients
To better understand why some cancer patients struggle to fight off infections, Georgia Tech researchers have created tiny lab-grown models of human immune systems.
Medical Xpress
Goblet cells could be the guardians of the gut
In a recent study, researchers at the University of California, San Diego, have provided new insights into the central role of goblet cells—specialized cells that line the gut—in maintaining a healthy and balanced immune environment within the gastroin…
Biomarker discovery offers a novel therapeutic approach for rheumatoid arthritis
Rheumatoid arthritis (RA) is the most common form of chronic inflammatory arthritis, characterized by synovitis and progressive destruction of bone and cartilage in the affected joints. Conventional synthetic disease-modifying antirheumatic drugs (csDM…
AI tools measure ‘immunological fitness’ to personalize cancer therapies
Researchers from the Data Science and Artificial Intelligence Institute (DATAI) at the University of Navarra have developed artificial intelligence (AI) models to personalize immune therapies for oncology patients.
New cancer therapy strategy targets GLUT3 in regulatory T cells to supercharge anti-tumor immunity
Scientists at Pohang University of Science and Technology (POSTECH) and ShanghaiTech University have achieved a breakthrough in cancer immunotherapy research. Led by Professors Sin-Hyeog Im and Dipayan Rudra, the research team, with Dr. Amit Sharma as …
Uncovering the mechanisms behind T cell differentiation
T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 cells, which fight against viruses and intracellular pa…
Glioblastoma: New treatment uses CAR-T cells to attack brain tumors from multiple angles
Glioblastoma is the most common kind of malignant brain tumor in adults. So far, no treatment has been able to make this aggressive tumor permanently disappear. The tumor cells are too varied, and the microenvironment is too tumor-friendly. Researchers…
Combination approach shows promise for treating rare, aggressive cancers
A research team led by UCLA Health Jonsson Comprehensive Cancer Center investigators has shown that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer an…
How immune cells ‘sniff out’ pathogens: Signaling study could speed up the search for new drugs
Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate TLRs, and what is the relationship between the scale and nature of this activatio…
Largest T cell clinical trial in solid tumors explores potential for precision immunotherapy
The largest ever clinical trial of T cell therapy for solid tumors has ended, heralding a new era for precision T cell therapy. Led by a Singapore clinician-scientist, the multinational, Phase III VANCE trial demonstrates that Singapore has the experti…