Exploring CAR T-cell therapy for aggressive follicular lymphoma
CAR T-cell therapy is an effective treatment for aggressive subtypes of follicular lymphoma, according to a clinical trial published in Nature Medicine.
Medical Xpress
Study identifies unpredicted immune responses to adenoviral COVID-19 vaccines
Researchers from the University of Liverpool’s Center for Drug Safety Science have identified unpredicted T-cell immune responses to the adenoviral (Oxford/AstraZeneca and Janssen) COVID-19 vaccines, but not to the mRNA vaccines.
Naturally occurring peptide could serve as a novel protective agent for ‘inflammaging’
A naturally occurring peptide called PEPITEM could potentially rejuvenate the immune response in older individuals and protect against “inflammaging,” which is widely believed to be the root cause of many age-related diseases.
Why the most prescribed chemotherapy drug can cause serious heart damage
There’s still much to learn about how doxorubicin, a 50-year-old chemotherapy drug, causes its most concerning side effects. While responsible for saving many lives, this treatment sometimes causes cardiac damage that stiffens the heart and puts a subs…
Immune cells monitor blood platelet maturation in bone marrow, researchers discover
Platelets play an essential role in wound healing. Underproduction can cause devastating bleeding, while overproduction increases the deadly risk of thromboses. Maintaining a constant level of platelets in the blood (homeostasis) is therefore vitally i…
Study shows autoantibodies behind lifelong risk of viral infection
A new study, published in the Journal of Experimental Medicine, shows that about 2% of the population develop autoantibodies against type 1 interferons, mostly later in life. This makes individuals more susceptible to viral diseases like COVID-19. The …
Q&A: Patterns and prognostications in immune-related adverse events from immunotherapy treatment
Yevgeniy Semenov, MD, MA, a physician-investigator in the Mass General Department of Dermatology and an Assistant Professor of Dermatology at Harvard Medical School, and Guihong Wan, Ph.D., an Instructor of Dermatology at Massachusetts General Hospital…
Study uncovers unknown interaction between leukemic cells and immune cells
The protein STAT3 helps the immune system to recognize leukemic cells. This interaction, which is important for future immunotherapies, is now understood in detail thanks to a study at the Karl Landsteiner University of Health Sciences (KL Krems).
Patient-driven discovery reveals potential target for autoimmune diseases
A medical mystery served as the genesis for a Yale-led study that has promising implications for treating a range of autoimmune diseases.
Study reveals dual role of protein in cancer treatment
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have uncovered new details about the role of a protein called interferon regulatory factor (IRF1) in cancer progression and treatment response, offering new insight that can potential…