The official results of the BRACELET-01 (PrECOG 0113) trial have been published in Clinical Cancer Research, detailing the safety and efficacy of pelareorep, an investigational oncolytic virus immunotherapy, when added to paclitaxel chemotherapy, both …
Colorectal cancer (CRC) is the second most common cause of death from cancer in the US and the most prevalent malignant tumor worldwide. CRC refers to cancer in the colon or rectum, the two parts that make up the large intestine. In the US, deaths from…
Neuroblastoma is a cancer that affects the sympathetic nervous system of children. It is unusual among cancers because it shows a range of outcomes: from aggressive, potentially fatal progression to a unique phenomenon where the tumor spontaneously reg…
Malaria is a life-threatening disease affecting people globally. It is spread by mosquitoes carrying Plasmodium parasites that infect and hide in red blood cells, making them difficult for the immune system to detect.
Organ transplant recipients with advanced cancer, an often overlooked group in cancer care, may benefit from immunotherapy drugs, according to a new study.
Monoclonal antibodies provide protection against a wide range of infectious microbes, and now, in a series of elegant laboratory experiments, scientists have uncovered how a pair of these lab-engineered molecules fight malaria.
Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease driven by calcium pyrophosphate dihydrate crystals, or C…
A new cancer treatment that delivers radiation directly to tumors by targeting two key markers simultaneously has been shown to be safe and effective in human trials. Acting like a “smart missile,” the dual-targeting radiopharmaceutical is designed to …
A research team has discovered a previously unknown mechanism that could explain why many patients with aggressive B-cell lymphoma do not respond to CAR-T cell therapy in the long term. The results of the study suggest that combining this innovative tr…
A rare gene mutation that delays Alzheimer’s disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell Medicine. The finding adds to growing evidence that br…
