Tricking tumors into marking themselves for destruction with focused ultrasound
USC biomedical engineers have found a way to make a solid tumor paint a target on its own back in order to train the body’s immune system to find and destroy it.
Medical Xpress
Farm-living families develop earlier immune maturation against food allergies, study finds
Children who grow up in farming communities have long been known to develop far fewer allergies than their urban peers. A new study from the University of Rochester Medical Center (URMC), offers one possible reason why: their immune systems may mature …
Preoperative radiation may improve antitumor immune response in most common form of breast cancer
Preoperative radiation improved T-cell infiltration (TCI) in patients with hormone receptor (HR)-positive, HER2-negative breast cancer when administered in combination with pembrolizumab (Keytruda) and chemotherapy and led to improved treatment respons…
Cell-free DNA could detect adverse events from immunotherapy
A noninvasive blood test to detect genetic material shed by tumors may help clinicians identify adverse events related to treatment with immune checkpoint inhibitor drugs, investigators at the Johns Hopkins Kimmel Cancer Center have found.
Off-the-shelf immunotherapy offers new hope for toughest myeloma
A new Mayo Clinic study published in the New England Journal of Medicine has uncovered that an off-the-shelf, dual-antibody therapy can generate deep and durable responses in extramedullary multiple myeloma—one of the most aggressive and treatment-resi…
New cancer therapy brings remission for patients with deadly T-cell leukemia
A small group of patients with an otherwise incurable form of T‑cell leukemia have seen their cancer driven into remission by an innovative form of immune therapy.
Study unveils improved mRNA cancer vaccine targeting
No matter where cancer cells grow in the human body, they are a threat to our health and our lives. But instead of treating them with chemotherapy or radiation—which have undesirable side effects—what if we could train our own immune systems to kill th…
Immune ‘switch’ identified as a potential target to curb chronic inflammation in cirrhosis
Chronic liver inflammation is one of the most serious complications associated with liver cirrhosis. Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified a molecular mechanism that acts as an immune “switch” and could po…
How can we better protect a transplanted kidney? AI-based antibody analytics point the way
When we think of kidney transplantation, we usually focus on surgery, immunosuppressive drugs, and early post-operative tests. Much less attention is paid to what happens months or years later, when a silent damaging process may begin inside the transp…
Specialized gut cells linked to celiac disease reveal new immune role
The human small intestine absorbs nutrients while protecting us from potentially harmful microbes. One of the cell types that plays a key role in this protection is the microfold cell (M cell). These cells detect bacteria and other foreign particles an…