‘Molecular shield’ placed in the nose may soon treat common hay fever trigger
Approximately 40% of the European population are allergic to pollen, and their symptoms cause an estimated loss of 100 million school and workdays every year.
Noticias
Most patients with advanced melanoma remain disease-free 4 years after pre-surgical immunotherapy, study finds
Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led by researchers at The Universit…
Microglia replacement halts progression of rare genetic brain disease in mice and humans
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset at 43 years and an average life expectancy of only three to five years after symptoms begin. ALSP is caus…
New survival benchmark for patients with advanced biliary tract cancer reached using combination therapy
In a follow-up analysis to the pivotal TOPAZ-1 study, which established the combination therapy of durvalumab (an immunotherapy drug) plus gemcitabine and cisplatin (GemCis, chemotherapy drugs) as the first-line treatment for people with advanced bilia…
Gene-editing platform could boost anti-cancer immune responses
Researchers have developed a new gene-editing platform that will enable safer and more effective T cell–based immunotherapies to treat cancer.
Chromosomal abnormality scores unlock path to personalized immunotherapy
In a newly published article in Nature Genetics, researchers from the University of Chicago have identified tumor aneuploidy—an imbalance in the number of chromosomes—as a powerful biomarker associated with resistance to immunotherapy across cancer typ…
Researchers identify project manager of the immune defense in the brain
Infections in the brain can have serious consequences and are often fatal. The immune defense system works differently here than in the rest of the body. A team of researchers at TWINCORE—Center for Experimental and Clinical Infection Research in Hanov…
Aggressive breast cancer triggered by obesity-related blood signals, study shows
Breast cancer is the most commonly diagnosed cancer among women worldwide and represents a major public health concern due to its high incidence and significant mortality rates. In the U.S. alone, approximately 297,790 new cases of invasive breast canc…
Novel T-cell subtypes in follicular lymphoma linked to patient prognosis
Researchers at University of Tsukuba have identified multiple T-cell subtypes with unique characteristics in follicular lymphoma, a prevalent type of blood cancer. These T cells regulate the proliferation and apoptosis of tumor cells and significantly …
Universal stem cells reset immunity in a systemic sclerosis patient
Research led by Naval Medical University’s Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman with systemic sclerosis.