PEPITEM sequence shows effects in psoriasis, comparable to steroid cream
Scientists have shown that a sequence of just three amino acids may reduce the severity of psoriasis, when applied topically in an emollient cream.
Noticias
‘Smart,’ ultrasound-activated immune cells may soon provide long-lasting tumor destruction
Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors—a smart fighter that destroys cancer cells for days without tiring. USC biomedical engineers have made this concept a reality, crafting what they have named t…
Researchers investigate characteristics of lymphocytes that prolong atopic dermatitis
Atopic dermatitis is an allergy affecting approximately 10% of the Japanese population, with symptoms closely related to social stress. In socially active adults, the disease often becomes chronic.
HLA-DRB1 molecule offers potential target for CAR therapy in relapsed acute myeloid leukemia post-transplantation
One main goal of anti-cancer therapies is to kill tumor cells without affecting the surrounding normal cells. Therefore, many drugs are designed to target tumor-specific antigens, which are molecules only expressed by cancer cells. However, it has prov…
Computational platform helps unlock A20’s dual role in cancer immunotherapy
There is an urgent need for precision immunotherapy strategies that simultaneously target both tumor cells and immune cells to enhance treatment efficacy. Identifying genes with dual functions in both cancer and immune cells opens new possibilities for…
Combination immunotherapy shrank a variety of metastatic gastrointestinal cancers
A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment’s effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial. …
Researchers develop test using machine learning to help predict immunotherapy response in lymphoma patients
A new article outlines a new tool that measures blood inflammation as a marker for poor CAR T therapy outcomes.
An immune cell may explain how maternal inflammation causes neurodevelopmental disorder
A research group has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. The research suggests the role of CD11c-positive microglia — immune cells in the brain crucial for myelination — during infant …
IL-7 treatment shows promise in reducing lethal secondary infections in critically ill COVID-19 patients
A new study published in JCI Insight suggests that interleukin-7 (IL-7), a key immune-boosting cytokine, may help critically ill COVID-19 patients by reducing life-threatening secondary infections. Led by Richard S. Hotchkiss, MD, professor of anesthes…
An immune cell may explain how maternal inflammation causes neurodevelopmental disorder
A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. The research suggests the role of CD11c-positive microglia—immune c…