One particular challenge in the treatment of cancer is therapy resistance. An international research team has now discovered a mechanism that opens up new treatment strategies for tumours in which conventional chemotherapeutic agents have reached their…
Manipulating the immune system to treat cancer has generated phenomenal responses in some patients, including complete cures, but those responses do not last for everyone. For example, chimeric antigen receptor (CAR) T–cell immunotherapy causes an init…
A bone marrow transplant process co-developed by investigators at the Johns Hopkins Kimmel Cancer Center is safe and curative for adults with sickle cell disease, according to results of a trial completed at Johns Hopkins and about 20 additional cancer…
Researchers have developed a novel antibody-toxin conjugate (ATC) designed to stimulate immune-mediated eradication of tumors. According to preclinical results, the approach combined the benefits of more well-known antibody-drug conjugates (ADCs) with …
CD8+ T cells accumulate in atherosclerotic plaques. Researchers identify a crucial signaling pathway — with therapeutic potential.
Researchers have shown that a particular type of immune cell acts more flexibly than previously thought — with potential for new therapeutic approaches.
Researchers have found that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins that cause diarrhea. Their findings show that these cells greatly increase in number when exposed to the cytokine i…
Researchers at the University of Texas MD Anderson Cancer Center have developed a novel antibody-toxin conjugate (ATC) designed to stimulate immune-mediated eradication of tumors. According to preclinical results published in Nature Cancer, the new app…
A significant number of Americans experience chronic inflammatory skin conditions with no pinpointed cause and often no effective treatments beyond symptom management. Now a new study could pave the way for precision-medicine-based diagnostic testing a…
Scientists at La Trobe University have identified a possible defense for humans against the influenza virus H5N1—commonly known as “bird flu”—which could open avenues of research for new vaccine development.
