A study just published in the journal Microbiome, describes for the first time the intestinal microbiome and metabolome in patients with (genetically acquired) CTLA4 deficiency. CTLA4 is an immune checkpoint, a key element in cancer mechanisms whose di…
New research has found that supplementing the maternal diet with α-tocopherol, a form of vitamin E, can reduce the development of food allergy and anaphylaxis in newborn mice.
Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.
Lupus can do irreversible harm to a person’s organs, damaging the lungs, kidneys, heart, liver and other vital organs through inflammation.
A sponge-like implant in mice helped guide a treatment that slowed or stopped a degenerative condition similar to multiple sclerosis in humans. It also gave researchers a look at how primary progressive multiple sclerosis, the fastest-progressing versi…
Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while avoiding its overactivation. However, the precise regulation…
Researchers are tackling neutrophilic asthma, successfully developing one of the first mouse models of the condition.
Researchers have developed a novel analytical method for tracking disease progression in patients that shows great potential for health care implementation.
Opioid use during pregnancy—whether of highly addictive drugs like fentanyl or controlled opioids like buprenorphine—doubles the risk of preterm birth. A new Yale study reveals that inflammation may be the culprit.
The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique.
