T cells rise up to fight infections in the gut
Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation — and relocation — as they fight infections in the small intestine.
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PET probe images inflammation with high sensitivity and selectivity
Researchers have developed a breakthrough method to detect inflammation in the body using positron emission tomography (PET) imaging. This innovative probe targets CD45, a marker abundantly expressed on all immune cells but absent from other cell types.
Injectable supramolecular hydrogel shows promise for neoadjuvant immunotherapy of triple-negative breast cancer
The efficacy of immunotherapy against triple-negative breast cancer (TNBC) heavily relies on intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Although neoadjuvant chemotherapy together with immunotherapy has been approved for advanced TNBC,…
Applied precision medicine: High-tech microscopy enables tailored rheumatology therapies
Rheumatoid arthritis is the most common inflammatory joint disorder, affecting over 60,000 people in Austria alone, with women being three times as likely to suffer from the condition as men. While treatment advances over the past decades have led to t…
Scientists discover how gut modulates development of inflammatory conditions
A study led by David Sancho at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid reveals how an increase in intestinal permeability allows the natural gut bacteria to cross the intestinal barrier and reach the bone marrow, where …
Immune cells’ location in the gut shapes their disease-fighting roles, study reveals
The human immune system is like an army of specialized soldiers (immune cells) each with a unique role to play in fighting disease. In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC …
Human papillomavirus infection kinetics revealed in new longitudinal study
Non-persistent human papillomavirus (HPV) infections are characterized by a sharp increase in viral load followed by a long plateau, according to a new study.
Study of deadly dog cancer reveals new clues for improved treatment
A research team has identified a crucial link between a gene mutation and immune system signaling in canine hemangiosarcoma, an aggressive cancer common in dogs. The discovery could lead to better treatments for both dogs and humans with similar cancers.
UK researchers call for renewed efforts in cancer vaccine development
UK oncology researchers have come together to write the first-ever national thought leadership strategy report into cancer vaccine advances and the opportunities these present for those affected by cancer. The strategy report has been published in the …
New effective treatment for deadly pancreatic cancer may be on its way
Pancreatic cancer is one of the deadliest of all cancers. Only 12% of men diagnosed with pancreatic cancer are alive five years after diagnosis; for women it is 14%.