Cancer Immunology Reserch

Lung cancer-intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg cell-dependent CD8+ T-cell exclusion

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Cancer Immunol Res. 2025 Jan 2. doi: 10.1158/2326-6066.CIR-24-0184. Online ahead of print. ABSTRACT Tumor cell-intrinsic signaling pathways can drastically affect the tumor immune microenvironment, promoting tumor progression and resistance to immunotherapy by excluding immune-cell populations from the tumor. Several tumor cell-intrinsic pathways have been reported to modulate myeloid-cell and T-cell infiltration creating “cold” tumors. However, … Read more

Profiling Multiple CD8+ T-Cell Functional Dimensions Enhances Breast Cancer Immune Assessment

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Cancer Immunol Res. 2024 Dec 23. doi: 10.1158/2326-6066.CIR-24-0235. Online ahead of print. ABSTRACT CD8+ T-cell abundance is insufficient to assess antitumor immunity and shows poor performance in predicting breast cancer prognosis and immunotherapy response, presumably owing to the complexity of CD8+ T-cell functionalities. While single-cell RNA sequencing (scRNA-seq) can dissect the multifaceted functions of CD8+ … Read more

Mathematical modeling predicts optimal immune checkpoint inhibitor and radiotherapy combinations and timing of administration

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Cancer Immunol Res. 2024 Dec 12. doi: 10.1158/2326-6066.CIR-24-0610. Online ahead of print. ABSTRACT Radiotherapy (RT) combined with immune checkpoint inhibitor (ICI) therapy has attracted substantial attention due to its potential to improve outcomes for patients with several types of cancer. However, the optimal administration timepoints and drug combinations remain unclear because the mechanisms underlying RT-induced … Read more

The FcγRIIIA (CD16) L48-H/R polymorphism enhances NK cell-mediated antibody-dependent cellular cytotoxicity by promoting serial killing

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Cancer Immunol Res. 2024 Dec 12. doi: 10.1158/2326-6066.CIR-24-0384. Online ahead of print. ABSTRACT Many tumor-specific monoclonal antibody therapies stimulate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells through FcγRIIIa (CD16). The efficacy of these ADCC-based immunotherapies is potentiated in patients with the common CD16 polymorphic variant F158-V that increases the binding affinity between the … Read more

The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response

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Cancer Immunol Res. 2024 Dec 12. doi: 10.1158/2326-6066.CIR-24-0250. Online ahead of print. ABSTRACT The precise mechanisms by which the complement system contributes to the establishment of an immunosuppressive tumor microenvironment (TME) and promotes tumor progression remain unclear. In this study, we investigated the expression and function of complement C5a receptor 1 (C5aR1) in human and … Read more

Tertiary lymphoid structures in pancreatic cancer are structurally homologous, share gene expression patterns and B-cell clones with secondary lymphoid organs but show increased T-cell activation

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Cancer Immunol Res. 2024 Dec 11. doi: 10.1158/2326-6066.CIR-24-0299. Online ahead of print. ABSTRACT Tertiary lymphoid structures (TLS) in cancer are considered ectopic hotspots for immune activation that are similar to lymphoid follicles in secondary lymphoid organs (SLO). This study elucidates shared and TLS/SLO-specific features in pancreatic ductal adenocarcinoma (PDAC). TLS abundance was related to superior … Read more

Identification and phenotypic characterization of neoantigen-specific cytotoxic CD4+ T cells in endometrial cancer

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Cancer Immunol Res. 2024 Dec 10. doi: 10.1158/2326-6066.CIR-24-0514. Online ahead of print. ABSTRACT Tumor-reactive CD4+ T cells often accumulate in the tumor microenvironment (TME) in human cancer, but their functions and roles in antitumor responses remain elusive. Here, we investigated the immunopeptidome of HLA class II-positive (HLA-II+) endometrial cancer with an inflamed TME using a … Read more

Natural killer cell-mediated cytotoxicity shapes the clonal evolution of B cell leukaemia

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Cancer Immunol Res. 2024 Dec 6. doi: 10.1158/2326-6066.CIR-24-0189. Online ahead of print. ABSTRACT The term cancer immunoediting describes the dual role by which the immune system can suppress and promote tumour growth and is divided into three phases: elimination, equilibrium and escape. The role of NK cells has mainly been attributed to the elimination phase. … Read more

The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment

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Cancer Immunol Res. 2024 Nov 27. doi: 10.1158/2326-6066.CIR-24-0713. Online ahead of print. ABSTRACT Regulatory T (Treg) cells play key roles in cancer immunity by suppressing a range of antitumor immune responses and contributing to resistance to programmed death (PD)-1 blockade therapy. Given their critical roles in self-tolerance, local control of immunosuppression by Treg cells, such … Read more

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