Curr Opin Immunol. 2024 Oct 1;91:102495. doi: 10.1016/j.coi.2024.102495. Online ahead of print. ABSTRACT Intricate immune regulation is required at mucosal surfaces to allow tolerance to microbiota and harmless allergens and to prevent overexuberant inflammatory responses to pathogens. The cytokine Interleukin-10 (IL-10) is a key mediator of mucosal immune regulation. While IL-10 can be produced by … Read more
Curr Opin Immunol. 2024 Sep 27;91:102488. doi: 10.1016/j.coi.2024.102488. Online ahead of print. ABSTRACT Immunoglobulin E (IgE)-mediated allergic diseases are driven by high-affinity allergen-specific IgE antibodies. IgE antibodies bind to Fc epsilon receptors on mast cells, prompting their degranulation and initiating inflammatory reactions upon allergen crosslinking. While most IgE-producing plasma cells have short lifespans, and IgE … Read more
Curr Opin Immunol. 2024 Sep 27;91:102489. doi: 10.1016/j.coi.2024.102489. Online ahead of print. ABSTRACT Inflammasomes are multiprotein signaling structures in the innate immune system that drive cell death and inflammatory responses. These protein complexes generally comprise an innate immune sensor, the adaptor protein ASC, and the inflammatory protease caspase-1. Inflammasomes are formed when a cytosolic sensor, … Read more
Curr Opin Immunol. 2024 Sep 13;91:102471. doi: 10.1016/j.coi.2024.102471. Online ahead of print. ABSTRACT The microbiome regulates mammalian immune responses from early life to adulthood. Antigen presentation, orchestrating these responses, integrates commensal and pathogenic signals. However, the temporal and spatial specificity of microbiome impacts on antigen presentation and downstream tolerance versus inflammation remain incompletely understood. Herein, … Read more
Curr Opin Immunol. 2024 Sep 13;91:102461. doi: 10.1016/j.coi.2024.102461. Online ahead of print. ABSTRACT T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has … Read more
Curr Opin Immunol. 2024 Sep 11;91:102462. doi: 10.1016/j.coi.2024.102462. Online ahead of print. ABSTRACT Signal integration is central to a causal understanding of appropriately scaled inflammatory responses. Here, we discuss recent progress in our understanding of the stimulus-response linkages downstream of pro-inflammatory inputs, with special attention to (1) the impact of cell state on the specificity … Read more
Curr Opin Immunol. 2024 Sep 25;91:102490. doi: 10.1016/j.coi.2024.102490. Online ahead of print. ABSTRACT Epithelial cells provide a first line of immune defense by maintaining barrier function, orchestrating mucociliary clearance, secreting antimicrobial molecules, and generating sentinel signals to both activate innate immune cells and shape adaptive immunity. Although epithelial alarmins play a particularly important role in … Read more
Curr Opin Immunol. 2024 Sep 24;91:102496. doi: 10.1016/j.coi.2024.102496. Online ahead of print. ABSTRACT Over the last 2 years, immunization disparities have surged due to a pandemic, violent conflicts, economic crises, and their disrupting effects on health care systems. This review provides a multilevel framework for understanding vaccination disparities and provides examples of work addressing disparities … Read more
Curr Opin Immunol. 2024 Sep 25;91:102492. doi: 10.1016/j.coi.2024.102492. Online ahead of print. ABSTRACT The global prevalence of atopic diseases, including food allergy, is increasing and correlates with shifts in the commensal microbiota triggered by modern lifestyle factors. Current research focuses on the immunological mechanisms and microbial cues that regulate mucosal immunity and prevent allergic responses … Read more
Curr Opin Immunol. 2024 Sep 24;91:102493. doi: 10.1016/j.coi.2024.102493. Online ahead of print. ABSTRACT The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, humans have been increasingly exposed to substances toxic for epithelial cells, including air pollutants, laundry and dishwashers, household chemicals, toothpaste, food additives, microplastics, … Read more
