Curr Opin Immunol. 2025 Oct 30;98:102685. doi: 10.1016/j.coi.2025.102685. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) are a rare subset of T cells that are potent regulators of the immune system. As a result, the use of Tregs to prevent undesired immune activation and to re-establish immune balance is an attractive cellular therapy approach. … Read more
Curr Opin Immunol. 2025 Oct 29;98:102686. doi: 10.1016/j.coi.2025.102686. Online ahead of print. ABSTRACT Complement inhibition has revolutionized the management of hemolytic diseases by targeting the underlying drivers of red blood cell destruction in disorders such as paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and cold agglutinin disease. Recent advances have expanded the therapeutic landscape beyond … Read more
Curr Opin Immunol. 2025 Oct 29;98:102687. doi: 10.1016/j.coi.2025.102687. Online ahead of print. ABSTRACT Excessive complement activation represents a major pathogenic mechanism for a range of serious human diseases. Complement-inhibitory therapeutics have been approved for a number of rare and ultra-rare conditions, with several others in clinical development. The vast majority of these complement-targeted drugs act … Read more
Curr Opin Immunol. 2025 Oct 27;97:102681. doi: 10.1016/j.coi.2025.102681. Online ahead of print. ABSTRACT Infectious agents are potential triggers for autoimmune diseases (ADs) in susceptible individuals, with infection being a key factor in initiating autoimmunity. Epidemiological and experimental evidence suggests molecular mimicry as a plausible mechanism for breaking peripheral tolerance, leading to clinical disease. However, molecular … Read more
Curr Opin Immunol. 2025 Oct 23;97:102682. doi: 10.1016/j.coi.2025.102682. Online ahead of print. ABSTRACT Malaria is a life-threatening disease affecting more than 200 million people worldwide. CD4 T helper 1 (Th1) and T follicular helper (Tfh) cells are critical for stimulating phagocyte activation and humoral immunity, yet sterilizing, protective immune memory responses rarely develop. Malaria induces … Read more
Curr Opin Immunol. 2025 Oct 17;97:102680. doi: 10.1016/j.coi.2025.102680. Online ahead of print. ABSTRACT While T cells play a prominent role, polymorphonuclear neutrophils (PMN) are also significant players in the pathogenesis of psoriasis. This review details the mechanobiology of PMN in the amplification of skin inflammation, a process often under-scrutinized compared to T cell pathways. PMN … Read more
Curr Opin Immunol. 2025 Oct 14;97:102678. doi: 10.1016/j.coi.2025.102678. Online ahead of print. ABSTRACT Neurotropic viruses represent a public health challenge due to their ability to cause severe neurological conditions, including meningitis, encephalitis, and paralysis. Although many studies have investigated the immune responses to viral infections in the brain and other nervous system targets, most have … Read more
Curr Opin Immunol. 2025 Oct 13;97:102679. doi: 10.1016/j.coi.2025.102679. Online ahead of print. ABSTRACT Sarcoidosis is a heterogeneous condition, with some presentations associated with spontaneous remission and favourable outcome without treatment. Other presentations, including small fibre neuropathy, arthropathy and sarcoid-associated fatigue, can cause disabling symptoms that may not respond to disease-modifying therapies and must be managed … Read more
Curr Opin Immunol. 2025 Oct 10;97:102676. doi: 10.1016/j.coi.2025.102676. Online ahead of print. ABSTRACT Allogeneic hematopoietic stem cell transplantation represents a curative treatment of choice for numerous severe hematological malignancies. While donor-derived transplanted T cells can limit disease relapse (GvT/GvL effect), they also induce, in 30-50% of the patients, acute graft-versus-host disease (aGvHD), a severe condition … Read more
Curr Opin Immunol. 2025 Oct 10;97:102675. doi: 10.1016/j.coi.2025.102675. Online ahead of print. ABSTRACT Allogeneic hematopoietic cell transplantation (HCT) can cure patients with high-risk hematologic malignancies. Donor T and natural killer (NK) cells contribute to graft-versus-leukemia (GVL) effects that provide relapse protection. Post-HCT relapses often represent inadequate GVL, but alloreactive lymphocytes that confer GVL may also … Read more
