Curr Opin Immunol. 2026 Jan 9;99:102714. doi: 10.1016/j.coi.2025.102714. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic, heterogeneous autoimmune disorder, clinically dominated by dryness symptoms resulting from inflammatory infiltration of exocrine glands. To date, no validated and resolutive therapeutic strategies are available. Stromal cells are increasingly recognized as critical players in SjD pathogenesis. … Read more

Curr Opin Immunol. 2026 Jan 9;99:102715. doi: 10.1016/j.coi.2025.102715. Online ahead of print. ABSTRACT Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating granulomas in various organs, predominantly affecting the lungs and lymphatic system. Although the etiology of sarcoidosis remains unknown, it is believed to result from an abnormal immune response triggered by environmental agents in … Read more

Curr Opin Immunol. 2026 Jan 8;99:102717. doi: 10.1016/j.coi.2025.102717. Online ahead of print. ABSTRACT We aim to present recent advancements in predictive markers for lymphomagenesis in SjD, concisely organize existing knowledge, and identify corresponding unmet needs and future perspectives. First, we briefly describe the mechanisms of lymphomagenesis in SjD. Followingly, the reasons justifying the importance of … Read more

Curr Opin Immunol. 2026 Jan 8;99:102716. doi: 10.1016/j.coi.2025.102716. Online ahead of print. ABSTRACT Sarcoidosis is a complex and heterogenous disease of which the diagnosis is based on clinical and radiological findings, histopathology showing non-caseating granulomas, and exclusion of other granulomatous diseases. Several tools are well established in the diagnostic pathway, such as pulmonary function tests, … Read more

Curr Opin Immunol. 2025 Dec 22;98:102712. doi: 10.1016/j.coi.2025.102712. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a chronic autoimmune disorder in which sustained B-cell activation drives glandular injury and systemic complications. Epithelial stress and interferon tone amplify B-cell activating factor (BAFF)-dependent survival, skewing selection toward autoreactive clones in both glands and blood. In addition, … Read more

Curr Opin Immunol. 2025 Dec 22;98:102713. doi: 10.1016/j.coi.2025.102713. Online ahead of print. ABSTRACT The intestinal microbiota transforms dietary components into bioactive metabolites that profoundly influence mucosal and systemic immunity. Short-chain fatty acids, secondary bile acids and tryptophan-derived indoles are among the most studied microbial metabolites shaping T, B and innate immune cell functions through a … Read more

Curr Opin Immunol. 2025 Dec 19;98:102711. doi: 10.1016/j.coi.2025.102711. Online ahead of print. ABSTRACT The complement system is a central component of innate immunity, mediating opsonization, chemotaxis, cytolysis, and shaping adaptive responses. Deficiencies in complement proteins, whether inherited or acquired, predispose to severe infections, particularly with encapsulated bacteria such as Neisseria meningitidis and Streptococcus pneumoniae. Although … Read more

Curr Opin Immunol. 2025 Dec 16;98:102709. doi: 10.1016/j.coi.2025.102709. Online ahead of print. ABSTRACT Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating epithelioid granulomata, most commonly involving the lungs and thoracic lymph nodes. Although definitive diagnosis relies on tissue biopsy, characteristic findings detected on computed tomography (CT) often allow a confident diagnosis. Atypical imaging patterns, … Read more

Curr Opin Immunol. 2025 Dec 16;98:102705. doi: 10.1016/j.coi.2025.102705. Online ahead of print. ABSTRACT Despite multiple alloantigenic differences in every allotransfusion, only 3-6% of transfusion recipients develop a detectable alloantibody even with multiple transfusions. Moreover, patients typically become alloimmunized only to some of the alloantigens to which they are exposed. In recent decades, precursor frequency of … Read more

Curr Opin Immunol. 2025 Dec 16;98:102710. doi: 10.1016/j.coi.2025.102710. Online ahead of print. ABSTRACT Indole is an abundant metabolite in the mammalian gut. Both mammals and microorganisms sense it. Indole is a signal used to communicate and gauge the gut environment. Indole is produced by bacteria that encode the tryptophanase enzyme. However, indole sensing is not … Read more