Current Opinion in Immunology

Curr Opin Immunol. 2025 Aug 14;96:102643. doi: 10.1016/j.coi.2025.102643. Online ahead of print. ABSTRACT Autoimmune skin diseases (AISDs) constitute a group of skin disorders driven by B cell-mediated autoimmunity or dysregulation of other immune cell populations. AISD can be further divided into systemic autoimmune disease with skin involvement, such as systemic lupus erythematosus (SLE), and skin-specific … Read more

Curr Opin Immunol. 2025 Aug 14;96:102636. doi: 10.1016/j.coi.2025.102636. Online ahead of print. ABSTRACT Psoriasis is a chronic autoimmune skin disease characterized by abnormal proliferation and differentiation of keratinocytes, with a complex pathogenesis often linked to environmental and genetic factors. Although many treatments are available, the disease still exhibits a high recurrence rate. Epigenetic regulation appears … Read more

Curr Opin Immunol. 2025 Aug 11;96:102632. doi: 10.1016/j.coi.2025.102632. Online ahead of print. ABSTRACT Juvenile idiopathic arthritis (JIA) is the most common rheumatological disorder affecting children. It is characterized by chronic synovial inflammation that may lead to permanent joint damage and disability. JIA is an umbrella term for a heterogenous group of subtypes based on specific … Read more

Curr Opin Immunol. 2025 Aug 9;96:102637. doi: 10.1016/j.coi.2025.102637. Online ahead of print. ABSTRACT Sarcoidosis is a systemic granulomatous disease of unknown cause that affects the lungs almost invariably. The clinical course and outcomes of pulmonary sarcoidosis are highly variable, ranging from mild and self-limiting to organ-threatening or life-threatening disease. Often, sarcoidosis remits permanently (spontaneously or … Read more

Curr Opin Immunol. 2025 Aug 7;96:102638. doi: 10.1016/j.coi.2025.102638. Online ahead of print. ABSTRACT Tuning complement activity is essential to maximize therapeutic efficacy while minimizing off-target effects in monoclonal antibody (mAb) design. Complement-enhancing strategies are primarily applied to mAbs targeting pathogens, infected cells, tumors, or immunosuppressive cells within the tumor microenvironment. In contrast, complement-silencing strategies are … Read more

Curr Opin Immunol. 2025 Aug 6;96:102629. doi: 10.1016/j.coi.2025.102629. Online ahead of print. ABSTRACT Macrophages and the complement system are fundamental components of innate immunity, emerging early in evolutionary history. The well-established functions of complement in relation to macrophages contribute to both innate and adaptive immunity and are mediated by extracellular components acting systemically or locally … Read more

Curr Opin Immunol. 2025 Aug 6;96:102628. doi: 10.1016/j.coi.2025.102628. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia. Complement system, which shares common actors with the coagulation cascade, is nowadays well established to be implicated in APS pathophysiology by different mechanisms. In APS, complement activation assessment is not included in the routine … Read more

Curr Opin Immunol. 2025 Aug 6;96:102631. doi: 10.1016/j.coi.2025.102631. Online ahead of print. ABSTRACT Neuropsychiatric lupus (NPSLE) is believed to manifest in 30-40% of SLE patients, with symptoms spanning from fatigue and anxiety to depression, cognitive impairment, and psychosis. Over the past decades, it has become clear that most animal models of SLE also present with … Read more

Curr Opin Immunol. 2025 Aug 5;96:102635. doi: 10.1016/j.coi.2025.102635. Online ahead of print. ABSTRACT Wound healing represents a dynamic process centered on the temporally coordinated inflammatory, proliferative, and remodeling phases. The inflammatory response exhibits a double-edged role: a moderate response is essential for normal healing, but excessive or persistent response impedes repair processes. In normal wound … Read more

Curr Opin Immunol. 2025 Aug 5;96:102610. doi: 10.1016/j.coi.2025.102610. Online ahead of print. ABSTRACT Antiphospholipid antibody syndrome (APS) is a vasculopathy with recurrent thrombosis and/or miscarriages mediated by autoantibodies against PL-binding proteins (aPL), mainly beta2glycoprotein I (β2GPI). While clotting is the key in vascular APS, thrombosis is not critical for placenta pathology. Despite that, anticoagulant/antiplatelet drugs … Read more