Current Opinion in Immunology

Curr Opin Immunol. 2026 Jun 22;101:102805. doi: 10.1016/j.coi.2026.102805. Online ahead of print. ABSTRACT Solid‑phase assays for the detection of antiphospholipid antibodies (aPL) are central to the laboratory evaluation of antiphospholipid syndrome (APS). Growing insights into the molecular immunology underlying these assays challenge traditional interpretations. It is now evident that the antigenic drivers are phospholipids (PL)‑binding … Read more

Curr Opin Immunol. 2026 Jun 16;101:102793. doi: 10.1016/j.coi.2026.102793. Online ahead of print. ABSTRACT The synovium is a critical site for the initiation and persistence of inflammatory joint diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), and gout. Conventional 2D cultures and animal models fail to recapitulate the multicellular organization, mechanical regulation, and inter-tissue communication that shape … Read more

Curr Opin Immunol. 2026 Jun 15;101:102802. doi: 10.1016/j.coi.2026.102802. Online ahead of print. ABSTRACT Lymphatic vessels maintain fluid balance and immune protection by transporting fluid, solutes and cells from tissue interstitial spaces to lymph nodes. The lymphatic endothelial cells that form lymphatics differentiate throughout the body to fulfil organ-specific roles. In the lungs, specialised pulmonary lymphatic … Read more

Curr Opin Immunol. 2026 Jun 13;101:102803. doi: 10.1016/j.coi.2026.102803. Online ahead of print. ABSTRACT Raynaud’s phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune connective tissue diseases such as systemic sclerosis, mixed connective … Read more

Curr Opin Immunol. 2026 Jun 4;101:102804. doi: 10.1016/j.coi.2026.102804. Online ahead of print. ABSTRACT Hantaviruses are enveloped, negative-sense RNA viruses. Rodents serve as natural reservoirs, and spillover into humans causes hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. While transmission typically occurs by inhaling aerosolized rodent excreta, the Andes virus variant is capable of human-to-human … Read more

Curr Opin Immunol. 2026 Jun 2;101:102790. doi: 10.1016/j.coi.2026.102790. Online ahead of print. ABSTRACT The tumor microenvironment (TME) is composed of diverse heterogeneous components and plays a crucial role in immune cell infiltration, immune evasion, and dynamic interactions between tumor cells and the immune system. A precise understanding of the TME is essential for tissue immunology … Read more

Curr Opin Immunol. 2026 May 29;101:102791. doi: 10.1016/j.coi.2026.102791. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is a thromboinflammatory disorder in which antiphospholipid antibodies (aPL), particularly anti-β2GPI, initiate a complex, graded platelet activation that integrates immune signaling with coagulation. Clinical and multiparametric flow-cytometric evidence demonstrates a sustained prothrombotic platelet endotype characterized by enrichment of tissue … Read more

Curr Opin Immunol. 2026 May 27;101:102792. doi: 10.1016/j.coi.2026.102792. Online ahead of print. ABSTRACT Sarcoidosis is a heterogeneous granulomatous disease of unknown origin; a subset of patients develops an advanced pulmonary disease phenotype, marked by progressive pulmonary fibrosis, airway involvement, and sarcoidosis-associated pulmonary hypertension, leading to high morbidity and mortality. In this review, we summarize key … Read more

Curr Opin Immunol. 2026 May 23;101:102789. doi: 10.1016/j.coi.2026.102789. Online ahead of print. ABSTRACT Traumatic knee injuries in skeletally immature patients occur in a unique biological context shaped by growth, high tissue turnover, and distinct immune-repair dynamics. Beyond structural damage, acute post-traumatic changes in synovial fluid and cartilage metabolism can set the trajectory toward persistent symptoms … Read more

Curr Opin Immunol. 2026 May 21;101:102785. doi: 10.1016/j.coi.2026.102785. Online ahead of print. ABSTRACT Despite the success of targeted therapies in rheumatoid arthritis, the lack of predictive biomarkers of response leads to an empirical treatment approach, often delaying effective intervention due to non-response to the initially selected individualized medication regimens in approximately 40% of patients. Cellular … Read more