Curr Opin Immunol. 2024 Oct 1;91:102484. doi: 10.1016/j.coi.2024.102484. Online ahead of print. ABSTRACT B cells experience extreme alterations in their metabolism throughout their life cycle, from naïve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the fastest rate of all cells, to long-lived plasma cells with very high … Read more
Curr Opin Immunol. 2024 Oct 1;91:102494. doi: 10.1016/j.coi.2024.102494. Online ahead of print. ABSTRACT The rise in the prevalence of allergic diseases has become a global health burden. Allergic diseases are a group of immune-mediated disorders characterized by IgE-mediated conditions resulting from a type 2 helper T cell (Th2)-skewed immune response. This review aims to comprehensively … Read more
Curr Opin Immunol. 2024 Sep 27;91:102488. doi: 10.1016/j.coi.2024.102488. Online ahead of print. ABSTRACT Immunoglobulin E (IgE)-mediated allergic diseases are driven by high-affinity allergen-specific IgE antibodies. IgE antibodies bind to Fc epsilon receptors on mast cells, prompting their degranulation and initiating inflammatory reactions upon allergen crosslinking. While most IgE-producing plasma cells have short lifespans, and IgE … Read more
Curr Opin Immunol. 2024 Sep 27;91:102489. doi: 10.1016/j.coi.2024.102489. Online ahead of print. ABSTRACT Inflammasomes are multiprotein signaling structures in the innate immune system that drive cell death and inflammatory responses. These protein complexes generally comprise an innate immune sensor, the adaptor protein ASC, and the inflammatory protease caspase-1. Inflammasomes are formed when a cytosolic sensor, … Read more
Curr Opin Immunol. 2024 Sep 25;91:102490. doi: 10.1016/j.coi.2024.102490. Online ahead of print. ABSTRACT Epithelial cells provide a first line of immune defense by maintaining barrier function, orchestrating mucociliary clearance, secreting antimicrobial molecules, and generating sentinel signals to both activate innate immune cells and shape adaptive immunity. Although epithelial alarmins play a particularly important role in … Read more
Curr Opin Immunol. 2024 Sep 24;91:102496. doi: 10.1016/j.coi.2024.102496. Online ahead of print. ABSTRACT Over the last 2 years, immunization disparities have surged due to a pandemic, violent conflicts, economic crises, and their disrupting effects on health care systems. This review provides a multilevel framework for understanding vaccination disparities and provides examples of work addressing disparities … Read more
Curr Opin Immunol. 2024 Sep 25;91:102492. doi: 10.1016/j.coi.2024.102492. Online ahead of print. ABSTRACT The global prevalence of atopic diseases, including food allergy, is increasing and correlates with shifts in the commensal microbiota triggered by modern lifestyle factors. Current research focuses on the immunological mechanisms and microbial cues that regulate mucosal immunity and prevent allergic responses … Read more
Curr Opin Immunol. 2024 Sep 24;91:102493. doi: 10.1016/j.coi.2024.102493. Online ahead of print. ABSTRACT The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, humans have been increasingly exposed to substances toxic for epithelial cells, including air pollutants, laundry and dishwashers, household chemicals, toothpaste, food additives, microplastics, … Read more
Curr Opin Immunol. 2024 Sep 21;91:102487. doi: 10.1016/j.coi.2024.102487. Online ahead of print. ABSTRACT A simple definition of life is a system that can self-replicate (proliferation) and self-sustain (metabolism). At the cellular level, metabolism has evolved to drive proliferation, which requires energy and building blocks to duplicate cellular biomass before division. T lymphocytes (or T cells) … Read more
Curr Opin Immunol. 2024 Sep 16;91:102460. doi: 10.1016/j.coi.2024.102460. Online ahead of print. ABSTRACT Since the discovery of Toll and Toll-like receptors (TLRs) in the 90s, an extensive body of research has been performed to determine how Pattern Recognition Receptors (PRRs) recognise ‘ligands’ and signal. The families of PRRs now include membrane and cytosolic proteins, which … Read more
