Current Opinion in Immunology

Curr Opin Immunol. 2025 Jun 17;95:102592. doi: 10.1016/j.coi.2025.102592. Online ahead of print. ABSTRACT Autoimmune diseases (AIDs) comprise a highly heterogeneous group of disorders with significant morbidity, disability, and mortality. Growing scientific evidence has suggested the interactions between genetic and environmental factors robustly involving in the pathogenesis of AIDs. Epigenetics serves as a critical bridge linking … Read more

Curr Opin Immunol. 2025 Feb;92:102524. doi: 10.1016/j.coi.2024.102524. Epub 2024 Dec 27. ABSTRACT The well-documented protumorigenic roles of macrophages in advanced cancers can sometimes overshadow their beneficial functions in the earlier stages of tumor development. This essay explores the hypothesis that macrophages play a crucial protective role in premalignant tissues by sensing and responding to early … Read more

Curr Opin Immunol. 2025 Jun 14;95:102586. doi: 10.1016/j.coi.2025.102586. Online ahead of print. NO ABSTRACT PMID:40517551 | DOI:10.1016/j.coi.2025.102586

Curr Opin Immunol. 2025 Jun 11;95:102585. doi: 10.1016/j.coi.2025.102585. Online ahead of print. ABSTRACT Spatial transcriptomics (ST) is a technology that has advanced our understanding of the cellular and genetic characteristics of conditions like psoriasis, cancer, and neurodegenerative diseases. ST is often used in conjunction with methods like single-cell RNA sequencing (scRNA-seq), which is a popular … Read more

Curr Opin Immunol. 2025 Jun 7;95:102568. doi: 10.1016/j.coi.2025.102568. Online ahead of print. ABSTRACT Once believed to be limited in its impact on the brain, the immune system is now recognized as a potent modulator of the brain and behavior. This review explores the evolving understanding of the brain-immune axis, highlighting the role of immune cells … Read more

Curr Opin Immunol. 2025 Jun 4;95:102584. doi: 10.1016/j.coi.2025.102584. Online ahead of print. ABSTRACT Immune tolerance is essential for preventing self-damage while maintaining effective immune responses against foreign insults. Disruptions in this balance contribute to autoimmune and inflammatory conditions, including neuroimmunological disorders that are characterized by aberrant inflammation in the nervous system. Follicular regulatory T (TFR) … Read more

Curr Opin Immunol. 2025 Jun 4;95:102579. doi: 10.1016/j.coi.2025.102579. Online ahead of print. ABSTRACT PURPOSE OF THE REVIEW: To provide an overview of animal models and mechanisms of autoimmune encephalitides associated with autoantibodies against neuronal surface antigens. PRINCIPAL FINDINGS: Currently, 18 encephalitides are known to be mediated by cell-surface autoantibodies, with 16 targeting neuronal proteins or … Read more

Curr Opin Immunol. 2025 May 31;95:102582. doi: 10.1016/j.coi.2025.102582. Online ahead of print. ABSTRACT The maintenance of peripheral tolerance depends on various regulatory mechanisms. Thus, the breakdown of self-tolerance leads to the development of autoimmunity. Although the pathogenesis of autoimmune diseases is complex, they are primarily antibody mediated. Notably, autoreactive antibodies are detectable in ∼70% of … Read more

Curr Opin Immunol. 2025 May 30;95:102583. doi: 10.1016/j.coi.2025.102583. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin condition that affects approximately 1%-3% of the global population. The advent of biologic therapies has markedly improved the management of moderate-to-severe cases. While the efficacy and safety of these novel agents are well documented, many patients … Read more

Curr Opin Immunol. 2025 May 31;95:102581. doi: 10.1016/j.coi.2025.102581. Online ahead of print. ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease that poses a serious threat to human physical and mental health. Its main clinical features include itching, lichenification, and dry skin. The etiology of AD is not yet fully understood, and its pathogenesis … Read more