Current Opinion in Immunology

Curr Opin Immunol. 2025 May 31;95:102582. doi: 10.1016/j.coi.2025.102582. Online ahead of print. ABSTRACT The maintenance of peripheral tolerance depends on various regulatory mechanisms. Thus, the breakdown of self-tolerance leads to the development of autoimmunity. Although the pathogenesis of autoimmune diseases is complex, they are primarily antibody mediated. Notably, autoreactive antibodies are detectable in ∼70% of … Read more

Curr Opin Immunol. 2025 May 30;95:102583. doi: 10.1016/j.coi.2025.102583. Online ahead of print. ABSTRACT Psoriasis is a chronic inflammatory skin condition that affects approximately 1%-3% of the global population. The advent of biologic therapies has markedly improved the management of moderate-to-severe cases. While the efficacy and safety of these novel agents are well documented, many patients … Read more

Curr Opin Immunol. 2025 May 31;95:102581. doi: 10.1016/j.coi.2025.102581. Online ahead of print. ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease that poses a serious threat to human physical and mental health. Its main clinical features include itching, lichenification, and dry skin. The etiology of AD is not yet fully understood, and its pathogenesis … Read more

Curr Opin Immunol. 2025 May 30;95:102580. doi: 10.1016/j.coi.2025.102580. Online ahead of print. ABSTRACT Vitiligo, characterized by epidermal melanocytes loss causing skin depigmentation, affects millions globally. This review explores its pathogenesis, emphasizing the role of epigenetic mechanisms such as DNA methylation, histone modification, noncoding RNAs, chromatin remodeling, and 3D genome regulation. These mechanisms interact with genetic … Read more

Curr Opin Immunol. 2025 May 30;95:102578. doi: 10.1016/j.coi.2025.102578. Online ahead of print. ABSTRACT The wide spectrum of Sjögren’s disease (SjD) clinical manifestations coupled with its multifaceted pathogenesis has complicated drug target development, optimal clinical trial design, identification of suitable SjD subgroups, selection of appropriate outcome measures, and interpretation of treatment efficacy. Despite recent advancements in … Read more

Curr Opin Immunol. 2025 May 30;95:102577. doi: 10.1016/j.coi.2025.102577. Online ahead of print. ABSTRACT Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle fatigability caused by autoantibodies targeting components of the neuromuscular junction, primarily the acetylcholine receptor (AChR). In AChR-MG, the thymus plays a central role as the initiating site of sensitization, fostering a highly … Read more

Curr Opin Immunol. 2025 May 27;95:102569. doi: 10.1016/j.coi.2025.102569. Online ahead of print. ABSTRACT Prevention remains a critical goal to improve quality of life, given the chronic nature of allergic conditions and the interplay between them contributing to the atopic march. In this review, we will highlight key novel approaches to preventing allergic disease using a … Read more

Curr Opin Immunol. 2025 May 26;95:102570. doi: 10.1016/j.coi.2025.102570. Online ahead of print. ABSTRACT Our body’s mucosal surfaces interface with the external environment and are potential sites of entry for pathogens as well as noxious substances. Yet, these barrier sites are also colonized with symbiotic microbes and are in contact with harmless environmental antigens. Different barrier … Read more

Curr Opin Immunol. 2025 May 26;95:102566. doi: 10.1016/j.coi.2025.102566. Online ahead of print. ABSTRACT Mitochondrial diseases (MtD) provide a unique window into the complex interplay between metabolism and immune function. These rare disorders, caused by defects in oxidative phosphorylation, result in bioenergetic deficiencies that disrupt multiple organ systems. While traditionally studied for their metabolic impact, MtD … Read more

Curr Opin Immunol. 2025 May 24;95:102565. doi: 10.1016/j.coi.2025.102565. Online ahead of print. ABSTRACT Autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis are well-defined autoimmune liver diseases, the pathophysiology of which remains enigmatic. While major therapeutic advances have been achieved for many other autoimmune diseases, precision therapy for these diseases has lagged. For example, limited … Read more