Curr Opin Immunol. 2024 Nov 19;91:102505. doi: 10.1016/j.coi.2024.102505. Online ahead of print. ABSTRACT Allergies are among the top causes of chronic disease in children. Their pathogenesis classically involves T helper 2 (Th2)-type inflammation driven by IgE-mediated allergen sensing. Triggers influencing allergic disease occur early in life, including before birth. The immature fetal immune system and … Read more
Curr Opin Immunol. 2024 Nov 14;91:102504. doi: 10.1016/j.coi.2024.102504. Online ahead of print. ABSTRACT The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell … Read more
Curr Opin Immunol. 2024 Nov 12;91:102502. doi: 10.1016/j.coi.2024.102502. Online ahead of print. ABSTRACT Much is known about the importance of macrophages for regulating diverse aspects of organismal physiology, alongside their essential roles in inflammation. Relatively unexplored are the processes influencing macrophages’ and monocytes’ ability to invade into the tissues where they carry out these functions. … Read more
Curr Opin Immunol. 2024 Nov 9;91:102501. doi: 10.1016/j.coi.2024.102501. Online ahead of print. ABSTRACT Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, … Read more
Curr Opin Immunol. 2024 Nov 8;91:102503. doi: 10.1016/j.coi.2024.102503. Online ahead of print. ABSTRACT Type 2 immune responses play a crucial role in host defense against parasitic infections but can also promote the development of allergies and asthma. This response is orchestrated primarily by group 2 innate lymphoid cells (ILC2) and helper type 2 (Th2) cells, … Read more
Curr Opin Immunol. 2024 Oct 31;91:102499. doi: 10.1016/j.coi.2024.102499. Online ahead of print. ABSTRACT As cancer immunotherapy evolves, tissue-resident memory (TRM) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal … Read more
Curr Opin Immunol. 2024 Oct 28;91:102500. doi: 10.1016/j.coi.2024.102500. Online ahead of print. ABSTRACT Allergic diseases continue to increase in prevalence across the globe. Decades of research has uncovered the cytokines and transcription factors that are central to the allergic immune response, but only in the last few years have we begun to understand the metabolic … Read more
Curr Opin Immunol. 2024 Oct 25;91:102498. doi: 10.1016/j.coi.2024.102498. Online ahead of print. ABSTRACT Aging is one of the greatest risk factors for several chronic diseases and is accompanied by a progressive decline of cellular and organ function. Recent studies have highlighted the changes in metabolism as one of the main drivers of organism dysfunctions during … Read more
Curr Opin Immunol. 2024 Oct 8;91:102472. doi: 10.1016/j.coi.2024.102472. Online ahead of print. ABSTRACT Successful treatment of infectious diseases requires a multiprong approach involving strategies that limit pathogen burdens and that limit disease. Traditionally, disease defense is thought to be a direct function of pathogen killing, and thus, our current methods for treating infections have largely … Read more
Curr Opin Immunol. 2024 Oct 4;91:102491. doi: 10.1016/j.coi.2024.102491. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) constitute the primary subset of immune cells within the tumor microenvironment (TME). Exhibiting both phenotypic and functional heterogeneity, TAMs play distinct roles in tumor initiation, progression, and responses to therapy in patients with cancer. In response to various immune … Read more
