Current Opinion in Immunology

Curr Opin Immunol. 2024 Oct 3;91:102497. doi: 10.1016/j.coi.2024.102497. Online ahead of print. ABSTRACT Neutrophils, the first responders of the innate immune system, can turn on a range of effector functions upon activation. Emerging research shows activated neutrophils undergo highly dynamic metabolic rewiring. This metabolic rewiring provides energy and reducing power to fuel effector functions and … Read more

Curr Opin Immunol. 2024 Sep 30;91:102482. doi: 10.1016/j.coi.2024.102482. Online ahead of print. ABSTRACT Five mammalian Toll-like receptors (TLR 3, 7, 8, 9, and 13) recognize nucleic acids (NA) and induce signals that control the function of multiple immune cell types and initiate both innate and adaptive immune responses. While these receptors enable recognition of diverse … Read more

Curr Opin Immunol. 2024 Sep 30;91:102486. doi: 10.1016/j.coi.2024.102486. Online ahead of print. ABSTRACT Emerging studies on the diet-immune axis have uncovered novel dietary immune regulators and identified crucial targets and pathways mediating the crosstalk between specific dietary components and diverse immune cell populations. Here, we discuss the recent discovery and mechanisms by which diet-derived components, … Read more

Curr Opin Immunol. 2024 Oct 1;91:102483. doi: 10.1016/j.coi.2024.102483. Online ahead of print. ABSTRACT T helper 2 (TH2) cells orchestrate type 2 immunity during protective antihelminth immunity and help restore tissue homoeostasis. Their misdirected activities against innocuous substances also underlie atopic diseases, such as asthma and allergy. Recent technological advances are uncovering novel insights into the … Read more

Curr Opin Immunol. 2024 Oct 1;91:102495. doi: 10.1016/j.coi.2024.102495. Online ahead of print. ABSTRACT Intricate immune regulation is required at mucosal surfaces to allow tolerance to microbiota and harmless allergens and to prevent overexuberant inflammatory responses to pathogens. The cytokine Interleukin-10 (IL-10) is a key mediator of mucosal immune regulation. While IL-10 can be produced by … Read more

Curr Opin Immunol. 2024 Oct 1;91:102485. doi: 10.1016/j.coi.2024.102485. Online ahead of print. ABSTRACT Aging, metabolism, and immunity have long been considered distinct domains. Aging is primarily associated with the gradual decline of physiological functions, metabolism regulates energy production and maintains cellular processes, and the immune system manages innate and adaptive responses against pathogens and vaccines. … Read more

Curr Opin Immunol. 2024 Oct 1;91:102484. doi: 10.1016/j.coi.2024.102484. Online ahead of print. ABSTRACT B cells experience extreme alterations in their metabolism throughout their life cycle, from naïve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the fastest rate of all cells, to long-lived plasma cells with very high … Read more

Curr Opin Immunol. 2024 Oct 1;91:102494. doi: 10.1016/j.coi.2024.102494. Online ahead of print. ABSTRACT The rise in the prevalence of allergic diseases has become a global health burden. Allergic diseases are a group of immune-mediated disorders characterized by IgE-mediated conditions resulting from a type 2 helper T cell (Th2)-skewed immune response. This review aims to comprehensively … Read more

Curr Opin Immunol. 2024 Sep 27;91:102488. doi: 10.1016/j.coi.2024.102488. Online ahead of print. ABSTRACT Immunoglobulin E (IgE)-mediated allergic diseases are driven by high-affinity allergen-specific IgE antibodies. IgE antibodies bind to Fc epsilon receptors on mast cells, prompting their degranulation and initiating inflammatory reactions upon allergen crosslinking. While most IgE-producing plasma cells have short lifespans, and IgE … Read more

Curr Opin Immunol. 2024 Sep 27;91:102489. doi: 10.1016/j.coi.2024.102489. Online ahead of print. ABSTRACT Inflammasomes are multiprotein signaling structures in the innate immune system that drive cell death and inflammatory responses. These protein complexes generally comprise an innate immune sensor, the adaptor protein ASC, and the inflammatory protease caspase-1. Inflammasomes are formed when a cytosolic sensor, … Read more