European Journal of Immunology – Page 44

Testosterone and estradiol reduce inflammation of human macrophages induced by anti‐SARS‐CoV‐2 IgG. [[{“value”:”Sona Allahverdiyeva, Chiara E. Geyer, Jennifer Veth, Laura M. de Vries, Steven W. de Taeye, Marit J. van Gils, Jeroen den Dunnen, Hung‐Jen Chen”}]]

30 de September de 202429 de September de 2024 by inmunoadmin

Older and obese individuals are at greater risk of developing severe COVID-19. In this paper, we identified that this may be related to decreased levels of testosterone and estradiol, by showing that these sex hormones reduce the excessive production of proinflammatory cytokines induced by anti-SARS-CoV-2 IgG antibodies. Abstract COVID-19, the disease caused by SARS-CoV-2, particularly … Read more

ThymoSpheres culture: A model to study human polyclonal unconventional T cells. [[{“value”:”Lore Billiet, Hanne Jansen, Melissa Pille, Lena Boehme, Guillem Sanchez Sanchez, Laurenz De Cock, Glenn Goetgeluk, Eva Pascal, Stijn De Munter, Lucas Deseins, Joline Ingels, Thomas Michiels, Robrecht De Vos, Amin Zolfaghari, Niels Vandamme, Jana Roels, Tessa Kerre, Ruslan I. Dmitriev, Tom Taghon, David Vermijlen, Bart Vandekerckhove”}]]

30 de September de 202429 de September de 2024 by inmunoadmin

ThymoSpheres provide an innovative, user-friendly in vitro model for generating mature, predominantly CD8 single positive T cells. These cells resemble human polyclonal αβ unconventional T cells in transcriptome and TCR repertoire characteristics, making this model valuable for studying the development of this specific T-cell lineage. Abstract In vitro cultures remain crucial for studying the fundamental … Read more