European Journal of Immunology

Licensing of MSCs with MIF requires CXCR4 receptor binding. Enhanced VEGF production by MIF-licensed MSCs promotes wound healing in vitro and can be blocked using the VEGFR2 inhibitor SU-5416. MIF-licensed MSC conditioned medium significantly reduced goblet cell hyperplasia in house dust mite-driven allergic airway inflammation in vivo. ABSTRACT Enhancing mesenchymal stromal cell (MSC) therapeutic efficacy … Read more

European Journal of Immunology, Volume 55, Issue 1, January 2025.

HTLV-1-infected T-cell lines suppress IgG and autoantibody production from B cells of healthy donors and patients with Sjögren’s syndrome through cell-to-cell contact and some humoral factors. ABSTRACT The reasons for the low frequency of anti-Ro/SS-A antibody in patients with HTLV-1-associated myelopathy complicated with Sjögren’s syndrome (SS) are unclear. In this study, we investigated whether HTLV-1-infected … Read more

Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

This study established a 21-day in vitro culture system for human long-lived plasma cells (LLPCs), demonstrating their survival and antibody secretion depend on stromal cell contact. PI3K and NF-kappaB pathways were crucial for LLPC survival, aligning with findings in mice. This model advances the understanding of human LLPC biology. ABSTRACT Contrary to short-lived plasma cells, … Read more

Allergen-specific antibodies can be detected in a large proportion of individuals. Still, only a fraction suffer from clinical signs of allergic disease, and of these, some, but not all, will develop more severe forms of the disease over time or respond to allergen-specific immunotherapy. Here, we review the concept of nonpathogenic versus pathogenic antibody responses … Read more

Sun et al. demonstrate that deficiency of macrophage-intrinsic Ubc13 increases Akt activation and PD-L1 expression, which triggers macrophage protumoral polarization and lung tumor progression. Ubc13-depletion in macrophage also increases infiltration of myeloid-derived suppressor cells and decreases proliferative and effector function of CD8+ T lymphocytes in the tumor microenvironment. ABSTRACT Tumor cell-intrinsic ubiquitin-conjugating enzyme Ubc13 promotes tumorigenesis, … Read more

ABSTRACT The journey of early-career researchers (ECRs) in immunology is marked by many challenges but also exciting prospects. Here we bring a snapshot of the recent ECR workshop organized by the Young European Federation of Immunology Societies (yEFIS) during the 7th European Congress of Immunology (ECI), which took place in Dublin Ireland from September 1 … Read more

This study demonstrates that CD27−CD21lo B cells harbor a relatively low frequency of somatic mutations in their BCR compared with CD27+CD21lo B cells and early plasmablasts. Clonal relationships were present among all three subsets in both health and disease, indicating that CD27−CD21lo B cells actively contribute to immune responses. ABSTRACT B cells with low or … Read more

Human CD8αβ was produced as an Fc-fusion via knob-in-hole mediated heterodimerization and bound class I pHLA and MR1 with similar affinity to human CD8αα, but did not bind CD1a, b, c, or d. An inverse relationship between CD8:pHLA affinity and TCR:pHLA was observed for several alleles. ABSTRACT The CD8 co-receptor exists as both an αα … Read more