Correction to “Tuning the Affinity of Chimeric Antigen Receptors Enhances the Function of Human Engineered Regulatory T Cells”.
European Journal of Immunology, Volume 56, Issue 7, July 2026.
European Journal of Immunology
The Respiratory Epithelial Barrier as an Immunopharmacological Rheostat: From Homeostatic Sentinel to Therapeutic Target in Chronic Lung Disease. [[{“value”:”Feng‐Xian Ni, Jie Hu, Hui‐Hui Chen, Dong‐Hui Huang, Ze‐Bo Jiang”}]]
This review introduces the “Epithelial Immunopharmacological Rheostat,” a framework where the respiratory epithelium calibrates immune tolerance versus inflammation through four interacting axes. Dysregulation of these axes drives chronic lung diseases, offering a roadmap for precision therapies that reset the rheostat. ABSTRACT The respiratory epithelium is a dynamic immunopharmacological interface that transcends its traditional role as … Read more
Engineering Soluble Recombinant BCMA for Ide‐Cel Labeling. [[{“value”:”Ly Phuong Vy Nguyen, Christelle Oblet, Alice Barbarin, Louis Waeckel, Farah Kotaich, Clara Petit, Marine Mabily, Claire Carrion, André Herbelin, Jean Marc Gombert, Xavier Leleu, Emilie Chalayer, Murielle Roussel, Patrick Legembre”}]]
This study describes the generation of a recombinant IFNα2-BCMAext-GFP probe, which enables sensitive detection of BCMA-directed CAR-T cells. The probe efficiently identifies idecabtagene vicleucel (ide-cel) CAR-T cells in patients with multiple myeloma and provides a simple alternative to current BCMA-based detection reagents. ABSTRACT Chimeric antigen receptor (CAR)-T-based strategies target the B-cell maturation antigen (BCMA) expressed … Read more
Inflammaging: Experimental Insights and Translational Advances. Andrea Cossarizza
Inflammaging is a chronic, low-grade, sterile inflammation associated with aging that contributes to age-related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome-based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease burden, and promote healthy aging. ABSTRACT Inflammaging, defined as the persistent, low-grade sterile inflammation accompanying … Read more
Caecal Epithelium‐Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm. [[{“value”:”Connor P. Lynch, Seona Thompson, Erin‐Claire Pallott, Laura Campbell, Sang Hun Lee, Richard K. Grencis”}]]
Immunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM-, Foxl1-, Ccl24- lamina propria-resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin TSLP has uncovered non-epithelial cellular sources of the cytokine … Read more
Hematopoietic Antigen Presenting Cells Fine‐Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells. [[{“value”:”Yi Wang, Trang T. Lam, Sotaro Ochiai, Abbie R. Larson, Dean B. Matthews, Hamish E.G. McWilliam, Tsuneyasu Kaisho, Mireille H. Lahoud, Jose A. Villadangos, Gretchen E. Diehl, Franca Ronchese, Daniel G. Pellicci, Mark M.W. Chong”}]]
Our study describes how the effector maturation of intrathymic iNKT and MAIT cells is guided by distinct hematopoietic APCs: DC1s for iNKT cells and macrophages for MAIT cells. ABSTRACT The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells, in the thymus is distinct from conventional … Read more
Complement Factor H‐Based Therapeutics: A Comprehensive Overview. [[{“value”:”Sebastiaan M. W. R. Hamers, Emmy J. Buter, Richard B. Pouw”}]]
Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H-based therapeutic concepts and modalities to treat complement-mediated diseases. ABSTRACT The complement system is a key component of innate immunity, modulating immunological processes to maintain … Read more
Altered TRPM3‐Dependent Cytosolic and Mitochondrial Calcium Influx in Natural Killer Cells of Post‐COVID‐19 Condition Patients. [[{“value”:”Chandi Tabeth Magawa, Natalie Eaton‐Fitch, Katsuhiko Muraki, Sonya Marshall‐Gradisnik”}]]
Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post-COVID-19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3-mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC. ABSTRACT According to the World Health Organization (WHO), … Read more
High‐Salt Diet Links Gut Microbiota, Intestinal Barrier Function, and Macrophage Responses. [[{“value”:”Akram Abdulkadyrov, Marie‐Louise Diefenbach‐Wilke, Elvira Mass, Maria Francesca Viola”}]]
This review examines how a high-salt diet disrupts gut microbiota composition, impairs intestinal barrier integrity, and modulates macrophage function, with a focus on their interconnection along the gut-liver axis. It highlights key methodological challenges, summarizes current mechanistic understanding, and identifies critical gaps for future research. ABSTRACT The Global North is increasingly exposed to a Western … Read more
Pam3CSK4 As a Second Hit in NLRP3‐Dependent Activation of Monocytes Primed With Antiphospholipid Antibodies. [[{“value”:”Anush Martirosyan, Eva Kriegova, Jana Ulehlova, Zaven Karalyan, Tomas Papajik, Gayane Manukyan”}]]
Pam3CSK4 amplifies aPL-induced monocyte activation. This results in thromboinflammatory activation that may contribute to APS-related vascular pathology. ABSTRACT Antiphospholipid antibodies (aPL) are drivers of inflammation and thrombosis in antiphospholipid syndrome (APS). However, the molecular mechanisms underlying infection-induced exacerbation of APS remain incompletely understood. To identify novel pathways contributing to the pro-inflammatory and pro-coagulant activation of … Read more