European Journal of Immunology

MRP8‐Cre Transgenic Mice Are Resistant to Weight Gain and Diet‐Induced Obesity Independently of Neutrophils. [[{“value”:”Stephan Forisch, Fatemeh Soltani, Laia Salvat Costa, Beatriz M. Cardoso, Yaiza Moreno Galiano, Cedric Duval, Robert A. S. Ariëns, Navdeep S. Chandel, Mari T. Kaartinen, Stefanie K. Wculek”}]]

by

The MRP8Cre mouse model is frequently used to investigate the biology of neutrophils. This study reports that MRP8Cre transgenic have a lower body weight and improved metabolic health, especially after high fat diet feeding, which correlates with decreased Serpine1/PAI-1 expression in metabolic organs. Image created with BioRender.com. ABSTRACT Obesity is a major risk factor for … Read more

A Multimodal Framework to Guide Solid Tumor Indications for Natural Killer Cell‐Based Therapy. [[{“value”:”L. Chiossone, V. Picant, Q. Barbier, T. A. Fehniger, Eric Vivier”}]]

by

This study integrates immunohistochemical evidence of NK cell infiltration in solid tumors, clinical outcomes of NK cell-based therapies, and transcriptomic analyses of more than 10,000 TCGA samples. Together, these complementary datasets provide a multimodal framework for prioritizing tumor indications and informing the rational design of future NK cell-based clinical trials. ABSTRACT T cell-based immunotherapies have … Read more

Loss of Neutrophils and SLPI Reshapes Early Mucosal Inflammatory Responses During Intranasal Vaccination. [[{“value”:”Oktawia Osiecka, Mariia Tyshchenko, Ivan Sinkevich, Natalia Pocałuń, Joanna Cichy, Jakub M. Kwiecinski, Ewa Oleszycka, Mieszko M. Wilk”}]]

by

Intranasal vaccination induces pulmonary neutrophil accumulation and SLPI release, accompanied by changes in soluble mediators associated with tissue remodelling, coagulation, and total IgA. ABSTRACT Vaccines delivered via the nasal route have attracted increasing attention for their capacity to engage the mucosal immune system at the primary site of pathogen entry. However, the early innate mechanisms … Read more

B‐Cell Remodeling and Regulatory Phenotypes During Acute COVID‐19 Are Unaffected by Polyclonal Anti‐SARS‐CoV‐2 Antibody XAV‐19. [[{“value”:”Nicolas Degauque, Richard Danger, Hoa Le Mai, Marion Cadoux, Thi‐Van‐Ha Nguyen, Gaëlle Tilly, François Raffi, Thomas Guimard, Karine Lacombe, Didier Laureillard, Laurent Hocqueloux, Vincent Dubee, Florence Ader, Cynthia Fourgeux, Jérémie Poschmann, Bernard Vanhove, Odile Duvaux, Benjamin Gaborit, Sophie Brouard, POLYCOR study group”}]]

by

SARS-CoV-2 infection drives transient B-cell remodeling toward an activated, regulatory-like phenotype. In this randomized sub-study, the polyclonal neutralizing antibody XAV-19 did not detectably alter B-cell phenotype, transcriptome, or function relative to placebo, indicating that passive polyclonal therapy preserves B-cell homeostasis during acute COVID-19. ABSTRACT Regulatory B cells (Bregs) are emerging as pivotal modulators of immune … Read more

The C‐Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus. [[{“value”:”Vladimir Bokun, Wengang Chai, Robert Buchanan, Elliot Murphy, Yan Liu, Beth Holder, Alexiane Decout”}]]

by

Whether viral lipids can directly interact with pattern recognition receptors to modulate antiviral immune responses remains unclear. We show that Mincle-dependent recognition of HCMV viral particles induces proinflammatory cytokine production in primary human macrophages. These findings demonstrate that Mincle recognition of HCMV lipid envelope constitutes a novel pattern recognition mechanism. ABSTRACT Enveloped viruses possess a … Read more

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells. [[{“value”:”Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr, Mara Schietinger, Thomas Wilhelm, Sandro Capellman, Michael Huber, Pardes Habib”}]]

by

(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP-1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP-1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation-induced cytokine secretion in BMMCs via the RAS/ RAF, HIF1α, and PI3K/AKT pathways. The graphical abstract was prepared … Read more

Functional and Proteomic Profiles of CD3(+) Plasma‐Derived Small Extracellular Vesicles Differentiate Cancer Patients From Healthy Donors. [[{“value”:”Piotr Widlak, Jie Han, Alicja Gluszko, Justyna Mika, Aneta Zebrowska, Sujan Kumar Mondal, Marta Gawin, Yana G. Najjar, Joanna Polańska, Monika Pietrowska, Theresa L. Whiteside”}]]

by

The graphical abstract illustrates MTEX-driven reprogramming of CD3(+) T cells in patients with melanoma. ABSTRACT Small extracellular vesicles (sEV) released by T cells play a key role in immune regulation. Immune capture with anti-CD3 antibodies was used to isolate and study T cell-derived CD3(+)sEV from the plasma of patients with melanoma (MPs) or healthy donors … Read more

Altered Peripheral and Synovial CD8+ T Cell Signatures Are Associated With Disease Activity in Female Early‐Stage Rheumatoid Arthritis. [[{“value”:”Lina Xu, Minghua Zhan, Zimo Wei, Shiran Dong, Fang Wang, Ziqin Zhao, Yudong Liu”}]]

by

Sex-biased synovial immunity features enhanced CCL3/CCL4-mediated CD8+ T-cell infiltration in female early-onset RA. This immune signature correlates with disease activity and fuels joint inflammation in female ERA patients. ABSTRACT Rheumatoid arthritis (RA) exhibits significant sexual dimorphism, with females being two to three times more susceptible than males. CD8+ T cells are key effector immune cells … Read more

Cellular and Humoral Immune Responses to Noncanonical Enterotoxigenic Escherichia coli Virulence Factors. [[{“value”:”Saman Riaz, Sehee Rim, Hans Steinsland, Oda Barth Vedøy, Tim J. Vickers, James M. Fleckenstein, Kurt Hanevik”}]]

by

Circulating antigen-reactive CD4+ T cells and antibody responses in serum and lavage against the ETEC noncanonical virulence factors EatA, EtpA, and YghJ were found in volunteers experimentally infected with ETEC. This documents the immunogenicity of these antigens and supports their further evaluation as ETEC vaccine candidates. ABSTRACT A broadly protective licensed vaccine against enterotoxigenic Escherichia … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri cURL Hatası: Could not resolve host: lkl.dolarkurum.com