J Clin Immunol. 2026 Feb 11. doi: 10.1007/s10875-026-01984-5. Online ahead of print. ABSTRACT Wiskott-Aldrich syndrome (WAS) is a rare x-linked monogenic immunodeficiency disease, caused by the mutation of WAS gene encoding WAS protein (WASp). Previous findings in WAS patients show B cell perturbations in the periphery, characterized by diminished B-cell numbers and phenotype abnormalities, including … Read more
J Clin Immunol. 2026 Feb 10;46(1):16. doi: 10.1007/s10875-025-01976-x. NO ABSTRACT PMID:41665758 | DOI:10.1007/s10875-025-01976-x
J Clin Immunol. 2026 Feb 7. doi: 10.1007/s10875-025-01979-8. Online ahead of print. ABSTRACT PURPOSE: Immunodysregulation, Polyendocrinopathy, Enteropathy, and X-linked (IPEX) syndrome is a rare autoimmune disorder caused by mutations in the FOXP3 gene. Patients with IPEX frequently present with severe dermatitis, diabetes, and enteropathy. This study explores the efficacy of Dupilumab (an anti-IL-4Rα monoclonal antibody) … Read more
J Clin Immunol. 2026 Feb 3. doi: 10.1007/s10875-025-01978-9. Online ahead of print. ABSTRACT PURPOSE: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is successful in pediatric patients with inborn errors of immunity (IEI), but its use in adults is complicated by pre-existing organ damage and increased risk of treatment-related mortality. Ex vivo graft engineering using αβTCR/CD19 depletion … Read more
J Clin Immunol. 2026 Feb 3. doi: 10.1007/s10875-026-01987-2. Online ahead of print. ABSTRACT PURPOSE: 22q11.2 Deletion Syndrome has been primarily described as a disorder of T cell production secondary to thymic hypoplasia. However, there is great complexity in the clinical picture with infections, autoimmunity, and inflammation occurring. Emerging evidence suggests that qualitative T cell dysfunction … Read more
J Clin Immunol. 2026 Feb 2;46(1):15. doi: 10.1007/s10875-026-01983-6. NO ABSTRACT PMID:41627598 | DOI:10.1007/s10875-026-01983-6
J Clin Immunol. 2026 Feb 2;46(1):14. doi: 10.1007/s10875-025-01941-8. NO ABSTRACT PMID:41627577 | DOI:10.1007/s10875-025-01941-8
J Clin Immunol. 2026 Feb 2. doi: 10.1007/s10875-026-01980-9. Online ahead of print. NO ABSTRACT PMID:41627524 | DOI:10.1007/s10875-026-01980-9
J Clin Immunol. 2026 Jan 27. doi: 10.1007/s10875-025-01968-x. Online ahead of print. ABSTRACT Behçet’s disease (BD) is a chronic inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, skin lesions, and uveitis. Recent genetic studies have identified monogenic diseases with phenotypes resembling BD, including RELA-associated inflammatory disease (RAID), Haploinsufficiency of A20 (HA20), and otulipenia. … Read more
J Clin Immunol. 2026 Jan 21;46(1):11. doi: 10.1007/s10875-026-01982-7. NO ABSTRACT PMID:41563625 | DOI:10.1007/s10875-026-01982-7
