J Immunol. 2024 Oct 25:ji2300858. doi: 10.4049/jimmunol.2300858. Online ahead of print. ABSTRACT Staphylococcus aureus is the major cause of healthcare-associated infections, including life-threatening conditions as bacteremia, endocarditis, and implant-associated infections. Despite adequate antibiotic treatment, the mortality of S. aureus bacteremia remains high. This calls for different strategies to treat this infection. In past years, sequencing … Read more

J Immunol. 2024 Oct 25:ji2400370. doi: 10.4049/jimmunol.2400370. Online ahead of print. ABSTRACT Flow cytometry is used for immune cell analysis for cell composition and function. Spectral flow cytometry allows for high-dimensional analysis of immune cells, overcoming limitations of conventional flow cytometry. However, analyzing data from large Ab panels is challenging using traditional biaxial gating strategies. … Read more

J Immunol. 2024 Oct 25:ji2400212. doi: 10.4049/jimmunol.2400212. Online ahead of print. ABSTRACT The role of the most common TP53 single-nucleotide polymorphism (SNP) at codon 72, which encodes for proline (P72) or arginine (R72), in the regulation of the immune system has not yet been thoroughly explored. We found that this SNP contributes to aggravated inflammatory … Read more

J Immunol. 2024 Oct 25:ji2400353. doi: 10.4049/jimmunol.2400353. Online ahead of print. ABSTRACT Abs play a pivotal role in adaptive immunity by binding to pathogens and initiating immune responses against infections. Processes such as somatic hypermutation and class switch recombination (CSR) enhance Ab affinity and effector functions. We previously carried out a CRISPR/Cas9 screen in the … Read more

J Immunol. 2024 Oct 23:ji2400326. doi: 10.4049/jimmunol.2400326. Online ahead of print. ABSTRACT Influenza virus is a highly contagious respiratory pathogen causing between 9.4 and 41 million infections per year in the United States in the last decade. Annual vaccination is recommended by the World Health Organization, with the goal to reduce influenza severity and transmission. … Read more

J Immunol. 2024 Oct 23:ji2300562. doi: 10.4049/jimmunol.2300562. Online ahead of print. ABSTRACT Chemokines play crucial roles in the regulation of immune cell migration and development. The CXCL12/CXCR4 axis has been extensively studied in mammals, but its regulatory mechanism in teleost fish remains unclear. In this study, we used Nile tilapia (Oreochromis niloticus) as a teleost … Read more

J Immunol. 2024 Oct 21:ji2400467. doi: 10.4049/jimmunol.2400467. Online ahead of print. ABSTRACT Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inflammation, for which there is no established treatment. In this study, we … Read more

J Immunol. 2024 Oct 21:ji2400420. doi: 10.4049/jimmunol.2400420. Online ahead of print. ABSTRACT Aptamers are short, single-stranded oligonucleotides that selectively bind to target biomolecules. Although they generally exhibit good binding specificity, their affinities are often limited because of the relative lack of hydrophobic groups in nucleic acids. Chemically modified nucleotides incorporating hydrophobic structures into uracil have … Read more

J Immunol. 2024 Nov 1;213(9):1267-1277. doi: 10.4049/jimmunol.2400020. ABSTRACT The human skin forms a dynamic barrier to physical injuries and microbial invasion. Constant interactions between stroma and tissue-confined immune cells maintain skin homeostasis. However, the cellular interactions that maintain skin health also contribute to focal immunopathology. Psoriasis is a common disease that manifests with focal pathology … Read more

J Immunol. 2024 Nov 1;213(9):1265. doi: 10.4049/jimmunol.2490015. NO ABSTRACT PMID:39432868 | DOI:10.4049/jimmunol.2490015