The Journal of Immunology

J Immunol. 2025 May 17:vkaf099. doi: 10.1093/jimmun/vkaf099. Online ahead of print. ABSTRACT We discovered a protective role of G protein-coupled receptor 3 (GPR3) in a mouse model of T cell-mediated autoimmune uveitis. GPR3 is an orphan receptor that maintains Gs-coupling and cyclic AMP production without an exogenous ligand. Consequently, GPR3 deficient (GPR3KO) mice were more … Read more

J Immunol. 2025 May 17:vkaf095. doi: 10.1093/jimmun/vkaf095. Online ahead of print. ABSTRACT Hepatitis B virus (HBV) infection remains a significant global health challenge, characterized by chronic liver inflammation and compromised antiviral immunity. The outcome of HBV infection and associated liver pathogenesis is influenced mainly by the host innate immune and inflammatory responses. Characterizing the mechanisms … Read more

J Immunol. 2025 May 17:vkaf105. doi: 10.1093/jimmun/vkaf105. Online ahead of print. ABSTRACT Immunological memory is a hallmark of the adaptive immune system. However, considerable evidence indicates that the natural killer (NK) cell subset of innate lymphoid cells also mediates specific memory responses to diverse antigens, including peptides. Even though the existence of NK cell memory … Read more

J Immunol. 2025 May 16:vkaf058. doi: 10.1093/jimmun/vkaf058. Online ahead of print. ABSTRACT Toll-interacting protein (Tollip) is an intracellular adaptor protein with diverse functions including regulation of autophagy of mitochondria-mitophagy. Tollip deficiency promotes viral infection, but whether mitophagy is involved remains unclear. We sought to determine if mitophagy and associated signaling such as mitochondrial DNA (mtDNA) … Read more

J Immunol. 2025 May 15:vkaf084. doi: 10.1093/jimmun/vkaf084. Online ahead of print. ABSTRACT Genetic modification of T cells to express chimeric antigen receptors (CAR, CAR-T cells) enable them to recognize the specific antigen on tumor surface and then eliminate the tumor. T lymphocyte ion channels such as Kv1.3, KCa3.1 and CRAC influence T cell activation and … Read more

J Immunol. 2025 May 15:vkaf049. doi: 10.1093/jimmun/vkaf049. Online ahead of print. ABSTRACT Atopic dermatitis (AD) and alopecia areata are highly prevalent inflammatory skin/hair conditions. While previously not fully understood and limited in treatment options, AD is currently undergoing a therapeutic revolution. Our increased understanding of the underlying immunologic and barrier dysregulations and disease heterogeneity across … Read more

J Immunol. 2025 May 15:vkaf091. doi: 10.1093/jimmun/vkaf091. Online ahead of print. ABSTRACT Secondary lymphoid organs (SLOs) provide a structured environment to facilitate interactions between low frequency antigen-specific B and T cells as well as cognate antigen displayed by antigen presenting cells (APCs), resulting in the initiation of effective adaptive immune responses. The spleen is the … Read more

J Immunol. 2025 May 15:vkaf087. doi: 10.1093/jimmun/vkaf087. Online ahead of print. ABSTRACT Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex heterogeneous multiorgan disease that can have severe impact on individuals’ quality of life. Diagnosis of ME/CFS is based on symptom presentation, and a significant goal for the field is to establish meaningful subtypes. The heterogeneity … Read more

J Immunol. 2025 May 14:vkaf076. doi: 10.1093/jimmun/vkaf076. Online ahead of print. ABSTRACT Human metapneumovirus (HMPV) is a leading cause of respiratory tract infection in pediatric, elderly, and immunocompromised populations. Clearance of HMPV relies primarily on the destruction of infected cells by cytotoxic CD8+ T cells. However, signals provided by CD4+ helper T cells significantly impact … Read more

J Immunol. 2025 May 13:vkaf056. doi: 10.1093/jimmun/vkaf056. Online ahead of print. ABSTRACT Leprosy is a neglected chronic infectious disease caused by Mycobacterium leprae or M. lepromatosis, representing a public health concern in several low-income countries. In Brazil, most patients develop lepromatous leprosy, a clinical form characterized by poor bacillary control due to T helper 2 … Read more