Trends Immunol. 2025 Jan 7:S1471-4906(24)00305-3. doi: 10.1016/j.it.2024.12.003. Online ahead of print. NO ABSTRACT PMID:39779379 | DOI:10.1016/j.it.2024.12.003
Trends Immunol. 2024 Dec 27:S1471-4906(24)00299-0. doi: 10.1016/j.it.2024.11.014. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but are frequently associated with immune-related adverse events (irAEs). This article offers a novel synthesis of findings from both preclinical and clinical studies, focusing on the molecular mechanisms driving irAEs across diverse organ systems. It … Read more
Trends Immunol. 2024 Dec 27:S1471-4906(24)00297-7. doi: 10.1016/j.it.2024.11.012. Online ahead of print. ABSTRACT Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid plexus, and perivascular spaces. These innate immune phagocytes are essential in brain development and maintaining homeostasis, but they … Read more
Trends Immunol. 2024 Dec 27:S1471-4906(24)00303-X. doi: 10.1016/j.it.2024.12.001. Online ahead of print. ABSTRACT Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator of immune response in the skin of affected individuals. Recognition of various mutations along the IL-36 axis and … Read more
Trends Immunol. 2024 Dec 24:S1471-4906(24)00304-1. doi: 10.1016/j.it.2024.12.002. Online ahead of print. ABSTRACT Tumor-initiating cells (TICs) are particularly efficient at evading detection and elimination by the human immune system. Recent data from Yang and collaborators demonstrate that – at least in preclinical hepatocellular carcinoma models – the immunological privilege of CD49f+ TICs can be limited by … Read more
Trends Immunol. 2024 Dec 20:S1471-4906(24)00296-5. doi: 10.1016/j.it.2024.11.011. Online ahead of print. ABSTRACT When B cells engage in an immune response, metabolic reprogramming is key to meeting cellular energetic and biosynthetic demands. Epstein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the human host’s lifetime. By hijacking signaling pathways of T cell-dependent … Read more
Trends Immunol. 2024 Dec 16:S1471-4906(24)00298-9. doi: 10.1016/j.it.2024.11.013. Online ahead of print. ABSTRACT Laboratory mice housed under specific pathogen-free (SPF) conditions are the standard model in biomedical research. However, experiments with a particular inbred mouse strain performed in different laboratories often yield inconsistent or conflicting data due to housing-specific variations in the composition and diversity of … Read more
Trends Immunol. 2024 Dec 12:S1471-4906(24)00295-3. doi: 10.1016/j.it.2024.11.010. Online ahead of print. ABSTRACT Biomolecular condensates are membraneless organelles formed through liquid-liquid phase separation. Innate immunity is essential to host defense against infections, but pathogens also harbor sophisticated mechanisms to evade host defense. The formation of biomolecular condensates emerges as a key biophysical mechanism in host-pathogen interactions, … Read more
Trends Immunol. 2024 Dec 10:S1471-4906(24)00280-1. doi: 10.1016/j.it.2024.11.009. Online ahead of print. ABSTRACT Gopee and colleagues’ recent analyses of diverse high-dimensional datasets of prenatal and adult skin, together with data from complex skin organoids, uncover the important contributions of macrophages in modulating prenatal skin development, scarless wound healing, and angiogenesis. These findings identify a role for … Read more
Trends Immunol. 2024 Nov 26:S1471-4906(24)00249-7. doi: 10.1016/j.it.2024.10.003. Online ahead of print. ABSTRACT The polycomb repressive complex 2 (PRC2) is an established therapeutic target in cancer. PRC2 catalyzes methylation of histone H3 at lysine 27 (H3K27me3) and is known for maintaining eukaryote cell identity. Recent discoveries show that modulation of PRC2 not only impacts cell differentiation … Read more
