Lung damage not main driver of persistent infections in cystic fibrosis, study finds
A new study meticulously sampled different lung regions in people with cystic fibrosis to understand why infections persist after new treatments.
Medical Xpress
Inactivation of key pathway boosts the body’s immune response against tumors
Immunotherapy uses the body’s immune system to recognize and destroy cancer cells. One way to do this is through immune checkpoint inhibitors.
Certain RNA modifications could contribute to the development of autoimmune disorders
New research published in Nature has uncovered powerful evidence that may explain why a new chemical modification of RNA is made in cells.
Replacing brain immune cells in mice slows neurodegeneration: Technique may help with diseases like Alzheimer’s
Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within the first years of life.
Computational tool ranks compounds to improve cancer immunotherapy effectiveness
A study published in Cell Reports Medicine reports a scalable, data-driven computational framework for designing combinatorial immunotherapies, offering hope for patients with poor responses to current immunotherapies.
Glucose helps T cells build cancer-fighting structures, not just provide energy
For cancer- and infection-fighting T cells, glucose offers far more than a simple sugar rush.
Boosting enzyme in brain immune cells could help treat Alzheimer’s disease
In a preclinical study, Cedars-Sinai investigators found that boosting angiotensin-converting enzyme (ACE) in key immune cells called microglia in the brain helped protect the brains of specially bred laboratory mice against Alzheimer’s disease. Their …
Study recommends starting immunotherapy for anti-igLON5 disease as early as possible
It often starts with restless sleep. Mobility, swallowing, and speaking disorders are also typical. Yet a range of other symptoms make it difficult to diagnose anti-IgLON5 disease. Left untreated, this rare autoimmune disease leads to severe disabiliti…
Preexisting anemia may make malaria worse, research finds
New research from The University of Toledo suggests that individuals with anemia may have a significantly higher risk of developing severe complications if they contract malaria. The findings were published this month in the peer-reviewed journal Infec…
Key protein Gfi1 found to regulate exhausted T cells in cancer and infection
Killer immune cells destroy cancer cells and cells infected by virus. These CD8+ T cells are activated after detection of viral infection or growth of “non-self” tumor cells. However, in chronic viral infection and cancer, the killer cells often lapse …