Kennedy researchers have uncovered key design parameters for bispecific T-cell engagers (TcEs)—a class of cancer immunotherapy drugs. The findings may help unlock the full potential of TcEs and revolutionize cancer treatment for patients.
Your T cells work hard to fight disease. Unfortunately, “friendly fire” from T cells can sometimes harm the body’s healthy tissues.
A more effective vaccine technology may be on the horizon. In a new study in mice, researchers from the University of Copenhagen demonstrate that a simple addition to mRNA vaccines can significantly enhance their effectiveness. The innovation could bec…
Researchers at the VIB-KU Leuven Center for Cancer Biology have uncovered that “natural killer” cells (NK), a type of immune cell, may actually be hindering the immune system’s ability to attack tumors in patients who don’t respond to immune checkpoint…
In the largest study of its kind, researchers from The University of Texas MD Anderson Cancer Center identified three subgroups of patients with large B-cell lymphoma (LBCL) who have different levels of benefit from CD19 chimeric antigen receptor (CAR)…
A team of physicians from Bochum are the first to successfully use CAR T-cell therapy to treat two patients with a rare autoimmune disease of the peripheral nervous system. This treatment modifies endogenous immune cells such that they can specifically…
Proteoglycans are large molecules that are important for tissues all over the body. For example, they play key roles in the development of cartilage and blood vessels, and they can also protect against inflammation and infection. But their role in canc…
For some, the word “histamine” might evoke thoughts of seasonal allergies: runny noses, scratchy throats and itchy eyes. But the molecule also influences exercise performance.
At the start of the COVID-19 pandemic, information began to trickle in about who was at higher risk of a dangerous outcome from infection: men, those over 65, smokers, those with obesity. It turns out these seemingly unrelated categories of people have…
Treating rare diseases can be complicated at the best of times, and it gets even more complicated when different patients with the same disease exhibit different symptoms. Now, researchers from Japan have reported a cellular signature that might explai…
