Understanding epigenetic control of antibody responses
Northwestern Medicine investigators have uncovered how antibody responses are regulated by epigenetic factors commonly mutated in cancers, according to a study published in Nature Immunology.
Medical Xpress
Hydrogel device enables painless transdermal delivery of nucleic acids for cancer immunotherapy
Nucleic acid (NA)-based medicine has been a focal point of research over the past two decades and has shown immense promise for both therapeutics and vaccines. The rapid development and deployment of NA-based vaccines during the COVID-19 pandemic under…
New clue into the curious case of our aging immune system
A WEHI study could help solve a long-standing mystery into why a key immune organ in our bodies shrinks and loses its function as we get older. The thymus is an organ essential for good health due to its ability to produce special immune cells that are…
Researchers discover new way inflammation impacts cell communication
Indiana University School of Medicine researchers have made significant progress in understanding how cells communicate during inflammation. The study, recently published in Proceedings of the National Academy of Sciences, was conducted over a period o…
Surprising mechanism of lupus kidney damage identified
A Berlin-led research team has uncovered critical regulators of severe kidney damage in patients with lupus, an autoimmune disorder affecting an estimated five million people worldwide, most of whom are young women. A small, specialized population of i…
Researchers find more effective way to deplete B-cells for the treatment of autoimmune disorders
B-cells protect your body from infection. But sometimes, they misfire and cause debilitating disease. Now, University of Connecticut researchers have shown that a single protein might be able to defuse B-cells gone bad. Their findings are published in …
Tracking influenza in its first battleground: The nose
The answer to curbing influenza could be right under our noses—or, more accurately, inside them. New research maps happenings in the nose during the course of influenza in exquisite detail, and could potentially lead to new targets and more effective n…
New TNIP1 mutation discovery offers fresh hope for disease that can cause blindness
An international team of scientists including researchers from The Australian National University (ANU) have identified a rare, mutated version of a protein called TNIP1 that causes a chronic autoimmune disease similar to Sjogren’s Syndrome—a condition…
Immune cell regulator discovery could lead to treatments for arthritis and severe COVID
The discovery of a new regulator affecting immune cells could lead to new treatments to reduce inflammation in diseases including arthritis and severe COVID 19.
Tackling cancer from the inside out: A deep dive into immune checkpoint inhibitors
In the past two decades, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, showing promising results against various solid tumors. A recent study reviews recent developments in ICIs, focusing on new targets like T cell immunorec…