Review explores potential of senescent cell-derived vaccines for cancer and aging
A new review paper titled “Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?” has been published in Aging.
Medical Xpress
The current state of immunotherapy in colorectal cancer
Colorectal cancer (CRC) is a major health concern worldwide, characterized by high incidence and mortality rates. Despite advances in treatment, metastatic CRC (mCRC) remains particularly challenging.
New therapy strengthens the immune system’s counterattack on skin cancer
An international research team has demonstrated a method to identify the cells in the immune system that can recognize and fight cancer cells in samples from 9 out of 10 patients affected by the rare but aggressive form of skin cancer, Merkel cell carc…
New antibody harbors great potential for fighting blood cancer
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. This form of blood cancer, which also occurs in adults, is caused by malignantly degenerated precursor cells of certain white blood cells (B-cell precursors or T-cells) that divi…
Protein may hold key to heart transplant tolerance
Northwestern Medicine investigators have uncovered how a protein contributes to heart transplant tolerance in mice, according to a study published in the Proceedings of the National Academy of Sciences.
Common respiratory infections may have protected children from COVID-19, study suggests
Analyzing nasal swabs taken during the pandemic, researchers at Yale School of Medicine suggest that the frequent presence of other viruses and bacteria may have helped to protect children from the worst effects of COVID-19 by boosting their immune sys…
Novel mechanism for targeting bone marrow adipocytes to prevent bone loss
Bone marrow adipocytes (BMAds) are situated within the bone microenvironment, in close proximity to bone cells, vascular structures, and hematopoietic tissues. The shift of bone marrow stromal/stem cells (BMSCs) lineage towards committed adipogenic pro…
Breakthrough research makes cancer-fighting viral agent more effective
When a cancer cell doesn’t respond to traditional therapies, doctors may turn to a sort of viral biological warfare, by deploying “troops” in the form of viral agents that are specifically engineered to target and eliminate cancer cells. The mode of at…
Chemical conjugation mitigates immunotoxicity of chemotherapy of lipid nanoparticles
While chemotherapy can stimulate antitumor immunity, it may also impair immune cell function and induce lymphodepletion, reducing the effectiveness of subsequent immunotherapy. Thus, nanoparticle-based drug delivery systems have been developed for thei…
Study suggests changing the gut microbiome improves health outcomes for newly-diagnosed metastatic kidney cancer
Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment …