Trends Immunol. 2025 Apr 15:S1471-4906(25)00081-X. doi: 10.1016/j.it.2025.03.007. Online ahead of print.
ABSTRACT
Epstein-Barr virus (EBV) was the first DNA virus identified to be tightly associated with multiple human tumors. It promotes malignant progression of tumors – including related lymphomas, nasopharyngeal carcinoma, and gastric adenocarcinoma – in part by evading surveillance and attack by the host immune system. In this article we review the main molecular mechanisms by which EBV-encoded proteins and RNAs interact with key molecules of the host immune system to inhibit Toll-like receptor (TLR)-nuclear factor κB (NF-κB), retinoic acid-inducible gene I (RIG-I), and interferon (IFN) signaling pathways, affect antigen presentation, prevent the cytotoxic effects of CD8+ effector cells, regulate the tumor microenvironment (TME) and cell metastasis and invasion, and inhibit cell apoptosis. These interactions not only contribute to the persistence of the virus but also provide potential targets for developing new immunotherapy strategies.
PMID:40240193 | DOI:10.1016/j.it.2025.03.007