J Leukoc Biol. 2025 May 27:qiaf074. doi: 10.1093/jleuko/qiaf074. Online ahead of print.
ABSTRACT
Neutrophils are traditionally known as short-lived pathogen-killing cells, but recent work published in Nature by Hidalgo and colleagues uncovers a novel role for neutrophils in maintaining skin integrity. Using transcriptomics, imaging, and genetic models, the study reveals that skin-infiltrating neutrophils produce collagen, particularly COL3A1, to regulate tissue mechanics and form matrix-rich “shields” that prevent pathogen entry. Collagen production by these specialized neutrophils in the skin was TGFβ-dependent and essential for wound protection, as its disruption led to disorganized skin architecture and increased bacterial invasion. This work redefines neutrophils as dynamic matrix-builders in barrier tissues, offering new insights into immune-tissue crosstalk and advancing our understanding of wound healing and host defense.
PMID:40424586 | DOI:10.1093/jleuko/qiaf074