J Leukoc Biol. 2026 Apr 2;118(4):qiag037. doi: 10.1093/jleuko/qiag037. NO ABSTRACT PMID:42047575 | DOI:10.1093/jleuko/qiag037
J Leukoc Biol. 2026 Apr 21:qiag051. doi: 10.1093/jleuko/qiag051. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a high-mortality lung disorder driven by excessive neutrophil activation. While neutrophils are central to ARDS, the metabolic pathways fueling their inflammatory response remain unclear. This study identifies CD177 as a critical regulator of neutrophil glycolysis and … Read more
J Leukoc Biol. 2026 Apr 28:qiag054. doi: 10.1093/jleuko/qiag054. Online ahead of print. ABSTRACT Skeletal muscle regeneration depends on coordinated interactions between macrophages, fibro-adipogenic progenitors (FAPs), and muscle stem cells (MuSCs). Following injury, macrophages transition from pro-inflammatory to anti-inflammatory phenotypes, regulating debris clearance, cytokine secretion, and the activity of FAPs and MuSCs. FAPs transiently support MuSC-mediated … Read more
J Leukoc Biol. 2026 Apr 25:qiag052. doi: 10.1093/jleuko/qiag052. Online ahead of print. ABSTRACT Exhausted T cells (Tex), characterized by impaired cytotoxic function, play a detrimental role in anti-tumor and anti-infection immunity but represent promising therapeutic targets for autoimmune diseases. Persistent exposure to auto-antigens drives autoreactive CD8+ or CD4+T cells toward an exhausted state, thereby mitigating … Read more
J Leukoc Biol. 2026 Apr 25:qiag053. doi: 10.1093/jleuko/qiag053. Online ahead of print. ABSTRACT HIV reservoirs persist in macrophages in people with HIV despite antiretroviral therapy, representing a barrier to cure. Factors which govern the establishment and reversal of HIV latency in different macrophage types remain poorly understood. An in vitro HIV latency model was used … Read more
J Leukoc Biol. 2026 Apr 25:qiag055. doi: 10.1093/jleuko/qiag055. Online ahead of print. ABSTRACT Eosinophils are challenging to profile by single cell RNA sequencing (scRNA-seq) approaches due to their fragile nature and the abundance of RNases and cytotoxic enzymes stored in cytoplasmic granules, which can compromise RNA integrity upon stress. Although recent technical advances have improved … Read more
J Leukoc Biol. 2026 Apr 15:qiag048. doi: 10.1093/jleuko/qiag048. Online ahead of print. ABSTRACT Neutrophils express Fc receptors on their surface to trap immune complexes. While the roles of FcγRIIa and FcγRIIIb have extensively been studied in that context, that of FcγRI remains elusive. Recently, aggregated IgGs have been shown to induce rapid FcγRI up-regulation and … Read more
J Leukoc Biol. 2026 Apr 9:qiag047. doi: 10.1093/jleuko/qiag047. Online ahead of print. ABSTRACT Trained innate immunity (TI) challenges the traditional view that adaptive immune cells are solely responsible for establishing immune memory. Instead, innate immune cells can develop a form of memory through persistent epigenetic, metabolic, and antimicrobial modifications, enabling them to respond to secondary … Read more
J Leukoc Biol. 2026 Apr 2;118(4):qiag040. doi: 10.1093/jleuko/qiag040. ABSTRACT Coiled-coil domain-containing proteins (CCDCs) play pivotal roles in tumorigenesis by regulating gene transcription, apoptosis, and cell cycle progression. This study focuses on the function and mechanisms of CCDC137 in acute myeloid leukemia (AML). Our findings revealed that CCDC137 is significantly overexpressed in AML and is closely … Read more
J Leukoc Biol. 2026 Apr 2;118(4):qiag027. doi: 10.1093/jleuko/qiag027. ABSTRACT The basis for differential susceptibility to Leishmania donovani infection observed in individuals remains poorly understood. Here we address this important open question comparing bone marrow-derived macrophages (BMDMs) from susceptible hamsters (hamBMDMs) and resistant mice (mBMDMs) to identify intrinsic cellular features that may contribute to host-specific outcomes. … Read more
