Journal of Leukocyte Biology

Rotavirus-specific intestinal resident memory T cells induced by oral vaccination in early-life mice may contribute to protective immunity​Catherine Montenegro on 13 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 13:qiag080. doi: 10.1093/jleuko/qiag080. Online ahead of print. ABSTRACT Resident memory T cells (Trm) are key mediators of protective immunity at barrier sites, yet their development during early life remains poorly defined. Here, we show that early-life oral vaccination with a heterologous rhesus rotavirus (RV) induces short-lived intestinal Trm that are … Read more

A Narrative Review of the mtDNA-Stimulated Inflammatory Axis in Sepsis-Induced Acute Lung Injury: Cellular Mechanisms and Therapeutic Targeting​Shuqi Ma on 11 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 11:qiag077. doi: 10.1093/jleuko/qiag077. Online ahead of print. ABSTRACT Sepsis-induced acute lung injury (SALI) represents a life-threatening condition with complex pathophysiology. Emerging evidence highlights the mitochondrial DNA (mtDNA)-stimulated inflammatory axis as a pivotal mechanism driving pulmonary inflammation. This narrative review elucidates how mtDNA, released upon cellular damage, acts as a potent … Read more

Conjugated bilirubin reduces hepatitis E virus infectivity by modulating immunometabolic processes​Javier Orozco-Cordoba on 11 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 11:qiag078. doi: 10.1093/jleuko/qiag078. Online ahead of print. ABSTRACT Despite the landmark discovery of the hepatitis E virus (HEV) four decades ago and its status as the leading cause of viral hepatitis worldwide, the infection remains overlooked in numerous countries. Currently, there are no approved treatments for hepatitis E or licensed … Read more

Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages​Sebastien Jacquelin on 10 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 10:qiag074. doi: 10.1093/jleuko/qiag074. Online ahead of print. ABSTRACT The proliferation, differentiation and survival of cells of the macrophage lineage depends on signals from the macrophage colony-stimulating factor receptor (CSF1R). On a C57BL/6J background homozygous kinase-dead Csf1r mutation (Csf1rE631K/E631K – E631Km/m) causes perinatal lethality. By contrast, E631Km/m mice on a mixed … Read more

Carboxylesterase 1 contributes to the human macrophage alternative activation response to Th2 cytokine interleukin-4​Matthew K Ross on 10 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 10:qiag073. doi: 10.1093/jleuko/qiag073. Online ahead of print. ABSTRACT Carboxylesterase 1 (CES1) is a hydrolytic enzyme with roles in xenobiotic and lipid metabolism. Our previous studies suggested a novel role for CES1 in the regulation of macrophage gene expression following exposure to inflammatory molecules. The nuclear receptor PPARγ has an important … Read more

Sombrero vesicles: from overlooked structures to primary mediators of eosinophil secretion​Rossana C N Melo on 6 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 5:qiag072. doi: 10.1093/jleuko/qiag072. Online ahead of print. ABSTRACT Eosinophils, cells of the innate immune system, have a unique architecture, which includes morphologically complex secretory granules and a prominent, activation-responsive vesiculotubular system. In human eosinophils, this system is collectively termed eosinophil sombrero vesicles (EoSVs) because of its peculiar morphology feasibly identifiable … Read more

SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques​Daniel I Petkov on 5 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 5:qiag069. doi: 10.1093/jleuko/qiag069. Online ahead of print. ABSTRACT People living with HIV experience an earlier risk for onset of aging-related chronic inflammatory comorbidities including cardiovascular disease. We previously showed that the proportion of macrophages was higher in the heart of older rhesus macaques (Macaca mulatta) with normal histopathology as well … Read more

Glucocorticoid-driven gene expression in circulating monocytes and neutrophils in health and severe inflammation​Arthur Molendijk on 4 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 4:qiag068. doi: 10.1093/jleuko/qiag068. Online ahead of print. ABSTRACT Glucocorticoids (GCs) are used as anti-inflammatory and immunosuppressive drugs in many immune mediated diseases, but their use in sepsis and shock is controversial. This is caused in part by a lack of information regarding the responding cell types and GC-regulated genes in … Read more

The Role of B cells in Idiopathic Inflammatory Myopathies​Raúl F Reyes-Huerta on 1 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 1:qiag071. doi: 10.1093/jleuko/qiag071. Online ahead of print. ABSTRACT Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation and systemic immune activation. Although traditionally viewed as T cell-driven diseases, recent evidence suggests that B lymphocytes may also contribute to disease mechanisms through both antibody-dependent … Read more

Beyond Suppression: The Plasticity, Dysfunction, and Therapeutic Reprogramming of Regulatory T Cells in Inflammatory Bowel Disease​Yunting Shao on 27 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 28:qiag067. doi: 10.1093/jleuko/qiag067. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gut, whose pathogenesis is closely related to immune dysregulation. Regulatory T cells (Tregs), as a key cell population maintaining intestinal immune tolerance, exhibit not only reduced frequency but, more critically, … Read more

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