Journal of Leukocyte Biology

J Leukoc Biol. 2025 Apr 17:qiaf049. doi: 10.1093/jleuko/qiaf049. Online ahead of print. ABSTRACT Neutrophils are the most abundant leukocytes in the circulation and critical players in host defense and inflammation. They respond rapidly to numerous biological, chemical, and physical stimuli, making it challenging to characterize their steady-state phenotypes, activation states, and subsets in an unbiased … Read more

J Leukoc Biol. 2025 Apr 17:qiaf047. doi: 10.1093/jleuko/qiaf047. Online ahead of print. ABSTRACT Bone marrow-derived dendritic cell (BMDC) activation is associated with rewiring of cellular metabolism and concurrent large-scale changes in gene expression promoting a pro-inflammatory program characterized by expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO). NO inhibits … Read more

J Leukoc Biol. 2025 Apr 16:qiaf045. doi: 10.1093/jleuko/qiaf045. Online ahead of print. ABSTRACT Dendritic cells (DCs) are rare innate immune cells that are essential regulators of anti-tumour, anti-viral and vaccine responses by the adaptive immune system. Conventional dendritic cells, particularly the cDC1 subset, are most desired for DC-based immunotherapies, however, it can be difficult to … Read more

J Leukoc Biol. 2025 Apr 16:qiaf044. doi: 10.1093/jleuko/qiaf044. Online ahead of print. ABSTRACT Natural Killer (NK cells) are known for their killing function in infection- and tumor-related responses, but also can shape immune responses involved in physiological processes such as wound healing. We recently reported that NK cells accumulate in skin wounds and express pro-inflammatory … Read more

J Leukoc Biol. 2025 Apr 15:qiaf043. doi: 10.1093/jleuko/qiaf043. Online ahead of print. ABSTRACT Recent studies have challenged the traditional view of innate immunity as non-specific and transient by demonstrating that innate immune cells can develop immune memory in response to various activating factors, a phenomenon known as trained immunity. This process involves epigenetic modifications, such … Read more

J Leukoc Biol. 2025 Apr 11:qiaf042. doi: 10.1093/jleuko/qiaf042. Online ahead of print. ABSTRACT Inhibiting the metabolic activity of CD4+ T cells can effectively reduce HIV infection. Mitochondria, as critical organelles in eukaryotic metabolism, play a significant role in the progression of many diseases. The change of mitochondrial dynamics is an important process of mitochondrial regulation … Read more

J Leukoc Biol. 2025 Apr 9:qiaf041. doi: 10.1093/jleuko/qiaf041. Online ahead of print. NO ABSTRACT PMID:40203078 | DOI:10.1093/jleuko/qiaf041

J Leukoc Biol. 2025 Apr 5:qiaf039. doi: 10.1093/jleuko/qiaf039. Online ahead of print. ABSTRACT Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms. Fatty acids, especially polyunsaturated fatty acids (PUFAs), are susceptible to … Read more

J Leukoc Biol. 2025 Apr 2:qiaf040. doi: 10.1093/jleuko/qiaf040. Online ahead of print. ABSTRACT Preterm neonates die at a significantly higher rate from sepsis than full-term neonates, attributable to their dysregulated immune response. In addition to tissue destruction caused directly by bacterial invasion, an overwhelming cytokine response by the immune cells to bacterial antigens also results … Read more

J Leukoc Biol. 2025 Mar 28:qiaf038. doi: 10.1093/jleuko/qiaf038. Online ahead of print. ABSTRACT BACKGROUND: Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. METHODS: Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in … Read more