Journal of Leukocyte Biology

J Leukoc Biol. 2026 Sep 8:qiag120. doi: 10.1093/jleuko/qiag120. Online ahead of print. ABSTRACT Although eosinophils are accepted as transcriptionally heterogeneous in asthma, how allergic inflammation shapes eosinophil states during influenza A virus (IAV) infection remains undefined. We integrated high-resolution single-cell RNA sequencing, spatial transcriptomics, quantitative immunofluorescence imaging, and cell-cell communication analyses to profile murine lungs … Read more

J Leukoc Biol. 2026 Sep 8:qiag122. doi: 10.1093/jleuko/qiag122. Online ahead of print. ABSTRACT Intra-tumoral T cell activity is required for effective anti-tumor immune responses and is partly regulated by tumor-associated neutrophils and macrophages. Here, we investigated the spatial context of neutrophil/macrophage interactions with CD8+ T cells in head and neck squamous cell carcinoma. Using multiplex … Read more

J Leukoc Biol. 2026 Sep 4:qiag121. doi: 10.1093/jleuko/qiag121. Online ahead of print. ABSTRACT As a scientist, teacher, research mentor, and mom, I asked myself, “what is my legacy?” Legacies usually have numbers associated with them. When asked this question in the past, I summed my accomplishments in terms of who, not what. First and foremost, … Read more

J Leukoc Biol. 2026 Aug 29:qiag118. doi: 10.1093/jleuko/qiag118. Online ahead of print. ABSTRACT Myeloid differentiation primary-response protein 88 (MyD88), an adapter protein used by many Toll-like receptors (TLRs), plays a critical role in initiating inflammatory responses. Our laboratory has previously shown that alcohol intoxication combined with burn injury causes intestinal tissue damage and leakiness. This … Read more

J Leukoc Biol. 2026 Aug 26:qiag119. doi: 10.1093/jleuko/qiag119. Online ahead of print. ABSTRACT Natural killer (NK) cells are active tumoricidal cells that inhibit esophageal cancer (EC) development, making them a prospective immunotherapeutic tool. Nonetheless, NK cells undergo both activation and exhaustion in the tumor microenvironment, but the related mechanisms have not been thoroughly understood. Using … Read more

J Leukoc Biol. 2026 Aug 20:qiag116. doi: 10.1093/jleuko/qiag116. Online ahead of print. ABSTRACT Natural killer (NK) cells stand as a critical pillar in the innate immune defense against viral infections, particularly human immunodeficiency virus (HIV). However, during HIV infection, NK cells demonstrate profound dysfunction, undermining effective immune control and accelerating disease progression along with viral … Read more

J Leukoc Biol. 2026 Aug 18:qiag115. doi: 10.1093/jleuko/qiag115. Online ahead of print. ABSTRACT Inflammation is a multifaceted response involving molecular and cellular components triggered by diverse stimuli, including physical, chemical, and biological factors. The connection between these stimuli and inflammatory cellular responses involves numerous interactions among molecular components, resulting in cell outputs that can either … Read more

J Leukoc Biol. 2026 Aug 14:qiag113. doi: 10.1093/jleuko/qiag113. Online ahead of print. ABSTRACT Myeloid cells orchestrate vascular inflammation through transcriptional programs that control their maturation, effector function, and survival. While lineage-determining transcription factors establish myeloid identity, our understanding of the transcriptional regulation of myeloid cell behavior in chronic inflammatory contexts remains limited. Nuclear factor-Y (NF-Y) … Read more

J Leukoc Biol. 2026 Aug 11:qiag114. doi: 10.1093/jleuko/qiag114. Online ahead of print. ABSTRACT NK cells effectively eliminate infected cells or tumour cells. The acquisition of cytotoxic functions occurs throughout NK cell functional maturation, a process that is commonly defined by the sequential expression of CD27 and CD11b. In addition, NK cell cytotoxicity is finely tuned … Read more

J Leukoc Biol. 2026 Aug 11:qiag110. doi: 10.1093/jleuko/qiag110. Online ahead of print. ABSTRACT Methylation of histone (H) 3 lysine (K) 4 has a well-established role in innate immune responses, but the contribution of H3K4 methyltransferases Kmt2c and Kmt2d in innate immunity is incompletely understood. Using conditional knockout (KO) mouse models, we investigated how Kmt2c- and … Read more