J Leukoc Biol. 2026 Jul 3;118(7):qiag101. doi: 10.1093/jleuko/qiag101. NO ABSTRACT PMID:42520763 | DOI:10.1093/jleuko/qiag101
J Leukoc Biol. 2026 Jul 23:qiag092. doi: 10.1093/jleuko/qiag092. Online ahead of print. ABSTRACT Natural killer (NK) cells are central to cancer immunosurveillance and immunotherapy. Their ability to engage in killing is critical for efficient target elimination and depends on tightly regulated Ca2+ signaling controlling granzyme degranulation. TLR engagement has been linked to Ca2+ signaling in … Read more
J Leukoc Biol. 2026 Jul 23:qiag092. doi: 10.1093/jleuko/qiag092. Online ahead of print. ABSTRACT Natural killer (NK) cells are central to cancer immunosurveillance and immunotherapy. Their ability to engage in killing is critical for efficient target elimination and depends on tightly regulated Ca2+ signaling controlling granzyme degranulation. TLR engagement has been linked to Ca2+ signaling in … Read more
J Leukoc Biol. 2026 Jul 22:qiag103. doi: 10.1093/jleuko/qiag103. Online ahead of print. ABSTRACT Patrolling monocytes (pMos) scavenge debris from vessel walls and mediate antibody-dependent cellular phagocytosis, making them attractive cell therapy candidates for cancer, atherosclerosis, and Alzheimer’s disease. However, methods to generate enhanced numbers of pMos are not available. To address this, we developed a … Read more
J Leukoc Biol. 2026 Jul 22:qiag102. doi: 10.1093/jleuko/qiag102. Online ahead of print. ABSTRACT Tissue-resident immune cells are specialized populations that survey peripheral tissues independently of circulating input. Their strategic positioning, persistence, and capacity for rapid local response make them key mediators of durable antitumor immunity. Although this biology has been most extensively defined in CD8+ … Read more
J Leukoc Biol. 2026 Jul 16:qiag098. doi: 10.1093/jleuko/qiag098. Online ahead of print. ABSTRACT Early and rapid identification of sepsis is critical for improving clinical outcomes; however, reliable real-time biomarkers remain unavailable. The scattergram parameters of peripheral blood circulating leukocytes are altered during infection and sepsis. This study aims to explore the cellular biological characteristics underlying … Read more
J Leukoc Biol. 2026 Jul 16:qiag100. doi: 10.1093/jleuko/qiag100. Online ahead of print. ABSTRACT Excess neutrophil apoptosis and the release of neutrophil extracellular traps (NETs) in systemic lupus erythematosus (SLE) leads to accumulation of cell debris and production of auto-antibodies targeting nuclear proteins and DNA. SLE neutrophil activation is regulated by changes in gene expression, notably … Read more
J Leukoc Biol. 2026 Jul 15:qiag099. doi: 10.1093/jleuko/qiag099. Online ahead of print. ABSTRACT Chronic lymphocytic leukemia (CLL) is a B-cell malignancy driven by aberrant signaling and microenvironmental support. Cytoskeletal remodeling contributes to these mechanisms, where the hematopoietic protein HS1 appears to play a key role. Thus, we generated C57BL/6 HS1 knockout (KO) mice to assess … Read more
J Leukoc Biol. 2026 Jul 13:qiag094. doi: 10.1093/jleuko/qiag094. Online ahead of print. ABSTRACT Hypereosinophilic syndrome (HES) is a rare hematopoietic disorder characterized by persistently elevated hypereosinophilia (HE) in peripheral blood and tissues, leading to multiorgan damage. HES can be classified into different subtypes based on diagnostic criteria and clinical characteristics: primary (neoplastic), secondary (reactive), idiopathic … Read more
J Leukoc Biol. 2026 Jul 10:qiag093. doi: 10.1093/jleuko/qiag093. Online ahead of print. ABSTRACT Interleukin (IL)-32 is recognized as a potent proinflammatory mediator in various infectious contexts, however, its precise contribution to host defense against Streptococcus pneumoniae (S. pneumoniae) remains to be fully elucidated. This study demonstrates that S. pneumoniae challenge robustly upregulates IL-32 expression in … Read more
