Trends Immunol. 2025 Nov 8:S1471-4906(25)00283-2. doi: 10.1016/j.it.2025.10.016. Online ahead of print.

ABSTRACT

HIV-1 persists lifelong despite effective antiretroviral therapy, yet the mechanisms underlying this persistence remain incompletely understood. Recent work by Wei et al. and Gao et al. reveals that the transcription factor BACH2 orchestrates CD4⁺ T cell memory programs fostering long-term memory formation while limiting effector differentiation, thereby promoting HIV-1 persistence.

PMID:41207817 | DOI:10.1016/j.it.2025.10.016