Trends Immunol. 2025 Nov 17:S1471-4906(25)00284-4. doi: 10.1016/j.it.2025.11.001. Online ahead of print.

ABSTRACT

Burn et al. reveal a previously unrecognised, non-catalytic function of myeloperoxidase (MPO) in neutrophil extracellular trap (NET) formation; integrating super-resolution microscopy and biochemical approaches, they demonstrated that MPO’s oligomeric state governs chromatin decondensation, redefining MPO as a structural chromatin modifier with implications for diseases driven by dysregulated NETosis.

PMID:41249077 | DOI:10.1016/j.it.2025.11.001