Trends Immunol. 2024 Sep 24:S1471-4906(24)00210-2. doi: 10.1016/j.it.2024.09.002. Online ahead of print.
ABSTRACT
Circulating immune cells contribute to the pathogenesis of Alzheimer’s disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17+ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion in neutrophils restored microglial responses and reduced murine amyloid pathology.
PMID:39322476 | DOI:10.1016/j.it.2024.09.002