Trends Immunol. 2024 Sep 27:S1471-4906(24)00212-6. doi: 10.1016/j.it.2024.09.004. Online ahead of print.
ABSTRACT
Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide lipids to mesenchymal tumor cells, thereby fueling glioblastoma growth.
PMID:39341708 | DOI:10.1016/j.it.2024.09.004