Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells​Phillip P Domeier on 7 de October de 2024 at 10:00

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J Leukoc Biol. 2024 Oct 7:qiae216. doi: 10.1093/jleuko/qiae216. Online ahead of print.

ABSTRACT

Thymic stromal lymphopoietin (TSLP) is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings that underpin our limited understanding of the role TSLP in modulating different stages of B cell development. We will also provide an overview of how TSLP drives B cell-mediated immune disease and how novel TSLP-blocking biologics could be used to modulate B cell responses. TSLP is critical for the regulation, diversity, and longevity of humoral immunity.

PMID:39373526 | DOI:10.1093/jleuko/qiae216

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