J Leukoc Biol. 2024 Oct 8:qiae221. doi: 10.1093/jleuko/qiae221. Online ahead of print.
ABSTRACT
A recent article in Cell reported a new peculiar interaction between mast cells and neutrophils. Upon IgE/Ag-mediated degranulation, mast cells (MCs) produce leukotriene B4 (LTB4), which attracts migrating neutrophils. Some neutrophils are able to establish close contact with MCs and end up trapped inside the MC, forming a cell-in-cell structure. While the neutrophil eventually dies inside the vacuole, the MC benefits from the remains of its prisoner, using it as a nutrient reserve and reusing its antimicrobial weapons.
PMID:39378340 | DOI:10.1093/jleuko/qiae221