Trends Immunol. 2024 Nov 27:S1471-4906(24)00275-8. doi: 10.1016/j.it.2024.11.004. Online ahead of print.
ABSTRACT
Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4+ T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L+ CD4+ T cells seems to sustain the local autoimmune response.
PMID:39603888 | DOI:10.1016/j.it.2024.11.004