J Immunol. 2024 Dec 15;213(12):1729-1737. doi: 10.4049/jimmunol.2400033.
ABSTRACT
Dysregulation of lipid homeostasis causes the deposition of lipids in the form of tiny droplets within foamy macrophages (FMs). In FMs, host-derived lipids aid in survival of various intracellular pathogens leading to sustained infection. In several infectious diseases, the transformation of macrophages into a foamy phenotype is linked to the presence of high IL-10, a potent immune-modulatory cytokine. This review aims to understand the role of IL-10 in the signaling events that are crucial in generation of FMs and highlights how various intracellular pathogens targets the IL-10-FM axis for successful establishment of infections. The review also briefly discusses how the IL-10-FM axis can be a target for developing novel therapeutic strategies to prevent intracellular infections.
PMID:39621957 | DOI:10.4049/jimmunol.2400033