J Leukoc Biol. 2024 Dec 17:qiae253. doi: 10.1093/jleuko/qiae253. Online ahead of print.
ABSTRACT
While widely viewed as inhibitory receptors that drive efferocytosis and immune resolution on myeloid cells, TAM family members, particularly Mertk, have emerged as promising targets in immune-oncology to help stimulate host anti-tumor immunity. A recent study shows that Mertk expressed on human T cells, including CD8+ T cells and differentiated central memory T cells, has a co-stimulatory function for the T Cell Receptor (TCR). These new findings reveal the complexity and diversification of Mertk in immune regulation and its implications to cancer therapeutics.
PMID:39686536 | DOI:10.1093/jleuko/qiae253