Trends Immunol. 2025 Jan 30:S1471-4906(25)00021-3. doi: 10.1016/j.it.2025.01.003. Online ahead of print.
ABSTRACT
The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing antiviral signaling and interferon expression to inhibit viral infection.
PMID:39890549 | DOI:10.1016/j.it.2025.01.003