Trends Immunol. 2025 Feb 26:S1471-4906(25)00031-6. doi: 10.1016/j.it.2025.02.004. Online ahead of print.
ABSTRACT
Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the membrane of neighboring cells, driving inflammatory cell death.
PMID:40016052 | DOI:10.1016/j.it.2025.02.004