Trends Immunol. 2025 Feb 28:S1471-4906(25)00034-1. doi: 10.1016/j.it.2025.02.007. Online ahead of print.
ABSTRACT
Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.
PMID:40023739 | DOI:10.1016/j.it.2025.02.007