Trends Immunol. 2025 May 26:S1471-4906(25)00123-1. doi: 10.1016/j.it.2025.05.002. Online ahead of print.
ABSTRACT
Understanding the mechanisms implicated in the establishment of trained immunity could aid the design of novel therapeutic approaches. By studying Bacille Calmette-Guerin (BCG) vaccination in a human cohort, Ziogas and colleagues demonstrate the role of lactate generation and its use for histone lactylation as a key mechanism for establishing innate immune memory.
PMID:40425374 | DOI:10.1016/j.it.2025.05.002